One shot during c-section may stop unbearable itching for moms with liver condition
NCT ID NCT07560722
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving a single intravenous dose of esketamine during a C-section can reduce the intense itching that often follows surgery in women with intrahepatic cholestasis of pregnancy. 160 women will be randomly assigned to receive either esketamine or a placebo (saline) right after delivery. The main goal is to see if itching scores drop within 24 hours, with follow-up at 72 hours.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Esketamine (a fast-acting anesthetic drug given by IV)
What this could lead to
If it works, this could offer a new way to ease severe itching after C-section for women with this liver condition, improving comfort without strong side effects.
What could go wrong
This is a small, early-stage trial with only 160 participants, so results may not apply to everyone. Esketamine can cause dizziness, nausea, or temporary dissociation, and the benefit over placebo is uncertain.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Tianjin Medical University General Hospital
Tianjin, 300052, China
Contact Phone: •••-•••-•••• Email: •••••@•••••