Cerebral amyloid angiopathy
MONDO:0005620Hereditary cerebral hemorrhage with amyloidosis (HCHWA) describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia.
Also known as: HCHWA, dutch hereditary cerebral amyloid angiopathy, hereditary cerebral haemorrhage with amyloidosis - Dutch type, hereditary cerebral hemorrhage with amyloidosis - Dutch type, CAA, familial, cerebral amyloid angiopathy, familial, cerebral amyloid angiopathy, genetic
30 clinical trials for this condition and its sub-types.
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Experimental drug aims to curb brain bleeds in rare genetic disease
Disease control OngoingThis study tests an experimental drug, NPI-001 (AT-001), in people with hereditary cystatin C amyloid angiopathy (HCCAA), a rare genetic condition that causes repeated brain bleeding and stroke. The trial includes about 15 participants aged 12 and older who carry the specific L68…
Phase: PHASE2 • Sponsor: Arctic Therapeutics • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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Can deep sleep or nerve stimulation flush toxic proteins from the brain?
Disease control ENROLLING_BY_INVITATIONThis Phase 2 trial tests whether a sleep-deepening drug (lower-sodium oxybate) or a nerve-stimulating device (non-invasive vagus nerve stimulation), or both, can help clear amyloid-beta protein from the brain in people with cerebral amyloid angiopathy (CAA). Sixty participants wi…
Phase: PHASE2 • Sponsor: Leiden University Medical Center • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Monthly MRI reveals hidden brain bleeding patterns in elderly
Knowledge-focused OngoingThis study uses monthly MRI scans to closely watch brain changes in 75 people with cerebral amyloid angiopathy (CAA), a condition common in older adults that can cause bleeding and strokes. Researchers aim to understand how small bleeds and silent strokes develop over time. Parti…
Sponsor: Martin Dichgans • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:35 UTC