Central sleep apnea syndrome
MONDO:0004731A broad classification of disorders which includes 6 subtypes (primary central sleep apnea, central sleep apnea due to Cheyne-Stokes breathing pattern, central sleep apnea due to medical condition not Cheyne-Stokes, central sleep apnea due to high-altitude periodic breathing, central sleep apnea due to drug or substance and primary sleep apnea of infancy) that are each characterized by interruptions in breathing while asleep. It is caused by improper signaling from the brainstem to respiratory muscles and is triggered by either hypoventilation or hyperventilation. In adults, this disorder may arise following a stroke, congestive heart failure, trauma, infection or the use of narcotic medications. It is more common in older males and may present as a co-morbid condition to obesity. Clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating and fatigue. Recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health.
Also known as: central sleep apnea syndrome, central sleep apnea, primary, primary central sleep apnea, secondary central sleep apnea, Apneas, central, Apneas, central sleep, Breathings, central sleep-disordered, alveolar hypoventilation, central
64 clinical trials for this condition and its sub-types, 21 tagged with Central sleep apnea syndrome itself.
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Browse by category →Sub-types of Central sleep apnea syndrome
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Complex sleep apnea 1 trial
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Drug induced central sleep apnea 1 trial
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Primary central sleep apnea syndrome 0 trials
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Can a chest patch outsmart sleep apnea diagnosis?
Diagnosis Recruiting nowThis trial evaluates a new chest patch sensor designed to monitor breathing movements and sleep position, which could improve the diagnosis of sleep apnea. The sensor aims to provide additional information beyond current fingertip sensors, potentially helping to distinguish betwe…
Sponsor: PranaQ Pte. Ltd. • Aim: Diagnosis
Last updated Aug 06, 2026 00:00 UTC
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New hope for better sleep after spinal injury
Symptom relief Recruiting nowThis study tests three approaches—oxygen therapy, the drug trazodone, and brief low-oxygen episodes—to see if they can improve sleep apnea in people with chronic cervical spinal cord injury. Researchers will measure changes in breathing and sleep quality in 100 participants. The …
Phase 4 • Sponsor: John D. Dingell VA Medical Center • Aim: Symptom relief
Last updated Jul 03, 2026 00:00 UTC
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Could a common drug fix sleep apnea and curb opioid cravings?
Symptom relief Recruiting nowThis study tests whether acetazolamide, a drug used for other types of sleep apnea, can help people on methadone or buprenorphine who develop central sleep apnea. Forty participants will take either the drug or a placebo for 7 days, then have an overnight sleep study. Researchers…
Phase 2 • Sponsor: Sanjay R Patel • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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Can a 45-Minute iPad test unlock how CCHS affects the brain?
Knowledge-focused Recruiting nowThis study measures thinking, memory, and attention in people with congenital central hypoventilation syndrome (CCHS), a rare condition that can reduce oxygen to the brain. Participants complete a 45-minute app-based cognitive assessment on an iPad, and parents or adult participa…
Sponsor: Ilya Khaytin • Aim: Knowledge-focused
Last updated Sep 05, 2026 00:00 UTC
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Veterans study aims to crack the code on Hard-to-Treat sleep apnea
Knowledge-focused Recruiting nowThis study looks at why central sleep apnea happens and how to treat it better. Researchers will test a combination of a drug (acetazolamide), extra oxygen, and a breathing machine (PAP therapy) in 200 veterans with this condition. The goal is to understand the body's breathing c…
Phase 4 • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jul 22, 2026 00:00 UTC
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Sleep apnea study aims to uncover key patterns in korean patients
Knowledge-focused Recruiting nowThis study is following 1,000 people in Korea who have symptoms of sleep apnea, like loud snoring or feeling very tired during the day. The goal is to learn more about the condition and how well patients stick with breathing machine therapy. Participants will have sleep tests and…
Sponsor: Seoul National University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Fixing heart valves may improve sleep apnea, new study investigates
Knowledge-focused Recruiting nowThis study watches 150 adults with heart valve problems who are getting a procedure (TAVI or M-TEER) to see if it helps their sleep-disordered breathing. Participants take a sleep test before the procedure and again 6 months later. The goal is to learn how fixing heart valves mig…
Sponsor: Aristides Plaitis • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC