Bunyaviridae infectious disease

This study looks at two drug combinations to treat BK virus infection in kidney transplant recipients. BK virus can cause the new kidney to fail. The trial compares everolimus with a lower dose of tacrolimus versus a lower dose of tacrolimus plus leflunomide in 50 adults whose vi…

This study aimed to see if a special blood filter (Seraph 100) could reduce BK virus levels in kidney transplant patients with high viral loads. It planned to enroll adults with a BK virus level of 10,000 IU/mL or higher who already had dialysis access. However, the trial was wit…

This study looks at whether a special team of doctors and nurses can treat adults with suspected infections at home, instead of sending them to the hospital. About 500 people will be randomly assigned to either standard hospital care or home-based care from a mobile response team…

This study tests a new way to treat viral infections that often occur after a solid organ transplant. Researchers create special immune cells, called viral-specific T-cells, from the patient's own blood to fight the virus. The goal is to reduce the need for strong anti-viral drug…

This study looks at how the immune system of patients in the intensive care unit (ICU) responds to severe infections caused by viruses or bacteria. Researchers will take extra blood samples from 38 adults to analyze immature granulocytes, a type of immune cell. The goal is to see…

This study reviews medical records of 50 adults who received a simultaneous liver-kidney transplant between 2015 and 2020. Researchers want to find out how many of them developed BK virus in their blood, which can harm the new kidney. The goal is to better understand this risk in…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study is testing whether a simple urine test can detect signs of kidney transplant rejection in children. Researchers are looking for specific molecules in urine that signal the body is attacking the new kidney. If the test works, it could help doctors spot problems early wi…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…