Botulism
MONDO:0005498A serious bacterial infection caused by botulinum toxin which is produced by Clostridium botulinum. Patients are infected usually by ingestion of contaminated food or wound contamination. It leads to muscle paralysis which may result in respiratory failure.
Also known as: botulism, botulism poisoning, food poisoning due to Clostridium botulinum, foodborne botulism, intoxication with Clostridium botulinum toxin, wound botulism (subtype), foodborne botulism (subtype), infant botulism (subtype)
5 clinical trials for this condition and its sub-types.
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Broader categories
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Booster shot could boost supply of lifesaving infant botulism treatment
Disease control CompletedThis study tested a single booster dose of a recombinant botulinum vaccine in 25 healthy adults who had already been vaccinated against botulism for work. The goal was to see if the booster safely raises their antibody levels enough to donate plasma for making BabyBIG, a treatmen…
Phase: PHASE2 • Sponsor: California Department of Public Health • Aim: Disease control
Last updated Aug 01, 2026 00:00 UTC
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Could a nerve drug help botulism patients breathe easier?
Disease control CompletedThis small pilot study tested a drug called 3,4-diaminopyridine (FIRDAPSE) in 3 people with severe botulism who needed a ventilator to breathe. The goal was to see if the drug could improve nerve signals and breathing. Because only 3 people took part, the results are very prelimi…
Phase: PHASE2, PHASE3 • Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Disease control
Last updated Jun 26, 2026 19:09 UTC
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New vaccine aims to block deadly botulism toxin
Prevention CompletedThis study tested an experimental vaccine (G03-52-01) in 622 healthy adults to see if it could safely protect against botulinum toxin, the poison that causes botulism. Participants received either the vaccine or a placebo, and researchers measured side effects and immune response…
Phase: PHASE2 • Sponsor: U.S. Army Medical Research and Development Command • Aim: Prevention
Last updated Jun 27, 2026 09:05 UTC
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Rare botulism cases reviewed to improve ICU care
Knowledge-focused CompletedThis study reviews the medical records of people who were hospitalized in French intensive care units (ICUs) for severe botulism poisoning. Botulism is a rare but serious illness caused by a toxin that can paralyze muscles. The goal is to describe what happened to these patients,…
Sponsor: Centre Hospitalier le Mans • Aim: Knowledge-focused
Last updated Jul 03, 2026 00:00 UTC