Autoinflammatory syndrome

MONDO:0019751

A group of disorders of the innate immune system characterized by attacks of seemingly unprovoked inflammation without significant levels of either autoantibodies or autoreactive T cells more characteristic of autoimmune disease.

208 clinical trials for this condition and its sub-types, 21 tagged with Autoinflammatory syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Syndromic disease (7158) ↑ Rheumatic disorder (1797)

Sub-types of Autoinflammatory syndrome

Sarcoidosis 62 trials · 85 incl. sub-types
8 sub-types
- Pulmonary sarcoidosis 20 trials
- Cardiac sarcoidosis 19 trials
- Blau syndrome 3 trials
- Skin sarcoidosis 3 trials
- Neurosarcoidosis 2 trials Sub-types →
- Löfgren syndrome 0 trials
- Hypercalcemic sarcoidosis 0 trials
- Uveoparotid fever 0 trials
Systemic-onset juvenile idiopathic arthritis 25 trials
Periodic fever syndrome 2 trials · 25 incl. sub-types
3 sub-types
- Hereditary periodic fever syndrome 5 trials · 24 incl. sub-types Sub-types →
- Periodic fever syndrome of childhood 0 trials
- Unexplained periodic fever syndrome 0 trials
Type 1 interferonopathy 4 trials · 21 incl. sub-types
9 sub-types
- Type 1 interferonopathy of childhood 0 trials · 19 incl. sub-types Sub-types →
- TREX1-related type 1 interferonopathy 0 trials · 5 incl. sub-types Sub-types →
- ADAR-related type 1 interferonopathy 0 trials · 1 incl. sub-types Sub-types →
- IFIH1-related type 1 interferonopathy 0 trials Sub-types →
- RNASEH2A-related type 1 interferonopathy 0 trials Sub-types →
- RNASEH2B-related type 1 interferonopathy 0 trials Sub-types →
- RNASEH2C-related type 1 interferonopathy 0 trials Sub-types →
- RNU7-1-related type 1 interferonopathy 0 trials Sub-types →
- SAMHD1-related type 1 interferonopathy 0 trials Sub-types →
Autoinflammatory syndrome of childhood 0 trials · 19 incl. sub-types
1 sub-type
- Type 1 interferonopathy of childhood 0 trials · 19 incl. sub-types Sub-types →
VEXAS syndrome 18 trials
Adult-onset Still disease 12 trials
Pyoderma gangrenosum 10 trials
4 sub-types
- Classic pyoderma gangrenosum 3 trials
- Bullous pyoderma gangrenosum 0 trials
- Pustular pyoderma gangrenosum 0 trials
- Vegetative pyoderma gangrenosum 0 trials
Idiopathic recurrent pericarditis 8 trials
PFAPA syndrome 6 trials
Chronic recurrent multifocal osteomyelitis 3 trials · 4 incl. sub-types
3 sub-types
- Sterile multifocal osteomyelitis with periostitis and pustulosis 2 trials
- Majeed syndrome 0 trials
- Chronic recurrent multifocal osteomyelitis 3 0 trials
SAPHO syndrome 3 trials
Schnitzler syndrome 1 trial
Cherubism 1 trial
1 sub-type
- Al Gazali Khidr Prem Chandran syndrome 0 trials
CEBPE-associated autoinflammation-immunodeficiency-neutrophil dysfunction syndrome 0 trials
F12-associated cold autoinflammatory syndrome 0 trials
PAPASH syndrome 0 trials
Pelger-Huet-like anomaly and episodic fever with abdominal pain 0 trials
SAMD9L-associated autoinflammatory syndrome 0 trials
Sharpin-related autoinflammatory syndrome 0 trials
Autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation 0 trials
Autoinflammatory disease, X-linked 0 trials
Autoinflammatory disease, multisystem, with immune dysregulation, X-linked 0 trials
2 sub-types
- Early-onset autoimmune disorder due to DOCK11 partial deficiency 0 trials
- Early-onset immune dysregulation due to DOCK11 complete deficiency 0 trials
Autoinflammatory disease, systemic, with vasculitis 0 trials
Autoinflammatory syndrome with immunodeficiency 0 trials
Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis 0 trials
Autoinflammatory syndrome, familial, Behcet-like 0 trials
2 sub-types
- Autoinflammatory syndrome, familial, Behcet-like 1 0 trials
- Autoinflammatory syndrome, familial, X-linked, Behcet-like 2 0 trials
Autoinflammatory syndrome due to TBK1 deficiency 0 trials
Early-onset pulmonary and cutaneous vasculitis 0 trials
Granulomatous autoinflammatory syndrome of childhood 0 trials
Infantile onset panniculitis with uveitis and systemic granulomatosis 0 trials
Magic syndrome 0 trials
Neonatal inflammatory skin and bowel disease 0 trials
2 sub-types
- Inflammatory skin and bowel disease, neonatal, 1 0 trials
- Inflammatory skin and bowel disease, neonatal, 2 0 trials
Neonatal-onset severe multisystemic autoinflammatory disease with increased IL18 0 trials
Psoriasis 14, pustular 0 trials
Pyoderma gangrenosum-acne-suppurative hidradenitis syndrome 0 trials
Pyogenic arthritis-pyoderma gangrenosum-acne syndrome 0 trials

Most studied deeper sub-types

Familial Mediterranean fever (15) Cryopyrin-associated periodic syndrome (10) Aicardi-Goutieres syndrome (9) CINCA syndrome (4) TNF receptor 1-associated periodic fever syndrome (4) Autoimmune interstitial lung disease-arthritis syndrome (3) Deficiency of adenosine deaminase 2 (3) Familial cold autoinflammatory syndrome (3) Mevalonate kinase deficiency (3) Muckle-Wells syndrome (3) Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (3) Aicardi-Goutieres syndrome 1 (2) Familial chilblain lupus (2) Hyperimmunoglobulinemia D with periodic fever (2) Periodic fever-infantile enterocolitis-autoinflammatory syndrome (2) Proteosome-associated autoinflammatory syndrome (2) STING-associated vasculopathy with onset in infancy (2) Cerebral sarcoidosis (1) Dyschromatosis symmetrica hereditaria (1) Proteasome-associated autoinflammatory syndrome 1 (1)

Including sub-types (208) Tagged with Autoinflammatory syndrome (21)

Trials to join now! 12 Not yet recruiting 4 Completed 5

Autoinflammatory syndrome

Where it sits in the disease tree

Most studied deeper sub-types

New drug combo aims to tame inflammation before stem cell transplant

New blood test could end Trial-and-Error for arthritis drugs

20,000 volunteers needed to decode immune disease genetics

Scientists seek genetic clues to mysterious fever diseases

Scientists launch deep dive into mysterious inflammatory diseases

Could the gut hold the key to calming autoinflammatory Flare-Ups?

Genetic hunt for hidden causes of mysterious inflammatory diseases

New study aims to unlock secrets of rare inflammatory diseases

Scientists launch hunt for clues in autoimmune skin diseases

Scientists hunt for hidden genes behind mysterious fevers

Scientists hunt for genetic clues in rare childhood immune disorders

Scientists investigate mysterious genetic variants behind rare inflammatory diseases