Alpha 1-antitrypsin deficiency
MONDO:0013282Alpha-1-antitrypsin deficiency is a hereditary disease that develops in adulthood and is characterized by chronic liver disorders (cirrhosis), respiratory disorders (emphysema), and rarely panniculitis.
Also known as: A-1ATD, A1AD, AAT deficiency, Alpha-1 Antitrypsin Deficiency, alpha 1-antitrypsin deficiency, deficiency in Alpa-1-proteinase inhibitor, emphysema due to AAT deficiency, emphysema-cirrhosis, due to AAT deficiency
43 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
-
Could an Anti-Inflammatory diet designed for Crohn's disease also tame IBS?
Disease control Not yet recruitingThis study tests whether a modified version of the Crohn's Disease Exclusion Diet (CDED) can ease symptoms of non-constipation irritable bowel syndrome (IBS) better than the standard low FODMAP diet. About 150 adults with moderate-to-severe IBS will follow one of the two diets fo…
Phase: NA • Sponsor: Ariel University • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
-
Can a higher dose slow lung damage in Alpha-1 patients?
Disease control Not yet recruitingThis study tests whether higher doses of the drug Respreeza/Zemaira can slow lung damage better than the standard dose in adults with emphysema caused by Alpha-1 antitrypsin deficiency. About 270 participants will receive weekly IV infusions for 3 years. The goal is to find the o…
Phase: PHASE4 • Sponsor: CSL Behring • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
-
New study aims to uncover hidden clues in rare liver disease
Knowledge-focused Not yet recruitingThis study follows 45 adults with alpha-1 antitrypsin deficiency (a genetic condition that can cause liver damage) to learn how the disease progresses. Researchers will analyze stored blood and liver tissue samples to find biomarkers and understand the molecular pathways involved…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
-
Rare gene defect may fuel liver cancer in otherwise healthy livers
Knowledge-focused Not yet recruitingThis study aims to find out how often a rare genetic condition called alpha-1 antitrypsin deficiency (AATD) occurs in people who develop liver cancer (hepatocellular carcinoma) but do not have cirrhosis or other known causes like hepatitis or heavy drinking. Researchers will look…
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC