Rare gene defect may fuel liver cancer in otherwise healthy livers

This study aims to find out how often a rare genetic condition called alpha-1 antitrypsin deficiency (AATD) occurs in people who develop liver cancer (hepatocellular carcinoma) but do not have cirrhosis or other known causes like hepatitis or heavy drinking. Researchers will look back at medical records of 71 adults with this type of liver cancer to see if AATD is a hidden risk factor. The results could help identify a new cause for some liver cancers.