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Agammaglobulinemia

MONDO:0015977

A decreased level of serum immunoglobulins. It may be inherited or acquired. It is caused by decreased or inefficient production of immunoglobulins from B cells or by a decrease in the numbers of B cells themselves. Low levels of immunoglobulins will affect the immune system's ability to combat bacterial infection. Supplementation of immunoglobulins is needed to prevent worsening outcomes.

Also known as: agammaglobulinemia, Gammaglobulin Deficiency, Immunoglobulin Deficiency, antibody Deficiency

128 clinical trials for this condition and its sub-types.

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Sub-types

Common variable immunodeficiency (27) Immunodeficiency 14 (6) Syndromic agammaglobulinemia (6) Activated PI3K-delta syndrome (5) Bruton-type agammaglobulinemia (4) Autosomal agammaglobulinemia (1) Immunodeficiency, common variable, 12 (1) Pancytopenia due to IKZF1 mutations (1) Agammaglobulinemia 10, autosomal dominant (0) Agammaglobulinemia 2, autosomal recessive (0) Agammaglobulinemia 3, autosomal recessive (0) Agammaglobulinemia 4, autosomal recessive (0) Agammaglobulinemia 5, autosomal dominant (0) Agammaglobulinemia 6, autosomal recessive (0) Agammaglobulinemia 7, autosomal recessive (0) Agammaglobulinemia 8, autosomal dominant (0) Agammaglobulinemia 8b, autosomal recessive (0) Agammaglobulinemia 9, autosomal recessive (0) Agammaglobulinemia, autosomal recessive, due to BOB1 deficiency (0) Agammaglobulinemia-microcephaly-craniosynostosis-severe dermatitis syndrome (0)

Broader categories

Disease (618) Hereditary disease (172) Hematologic disorder (160) Immune system disorder (140) Inborn error of immunity (113) Immunodeficiency disease (48) Human disease (14) Leukocyte disorder (5) B cell deficiency (4) Disease of genetic or genomic mechanism (2)
Trials to join now! 62 Not yet recruiting 12 Not yet finished but already full! 19 Completed 33 Terminated 2
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