New hope for cancer survivors: drug aims to shield against Life-Threatening infections

NCT ID NCT07648264

Not yet recruiting Disease control Sponsor: CSL Behring Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tests a drug called IgPro20 in 63 adults who have a weakened immune system after receiving CAR T-cell therapy for blood cancers like lymphoma or multiple myeloma. The goal is to see if the drug can lower the number of serious bacterial infections, such as pneumonia or sepsis. Participants will receive regular doses of IgPro20 and be monitored for infections and side effects over time.

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Conditions

The condition(s) this trial relates to.

agammaglobulinemia B-cell acute lymphoblastic leukemia B-cell chronic lymphocytic leukemia Burkitt lymphoma hematopoietic and lymphoid system neoplasm non-Hodgkin lymphoma plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SECONDARY IMMUNE DEFICIENCY

Contacts and locations

Locations

AZ Delta

Roeselare, West-Vlaanderen, 8800, Belgium
Aidport sp z o.o.

Skorzewo (Poznan), Wielkopolska, 60185, Poland
American Oncology Partners, PA dba The Center for Cancer and Blood Disorders

Bethesda, Maryland, 20817, United States
Azienda Ospedaliera Universitaria Careggi

Florence, 50134, Italy
Azienda Ospedaliero Universitaria Policlinico "Gaspare Rodolico - San Marco" (Presidio G. Rodolico)

Catania, 95124, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Montichiari)

Brescia, Lombardy, 25123, Italy
CBCI, Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States
CHU Angers - Hôpital Hôtel Dieu

Angers, Maine Et Loire, 49933 Angers Cedex 09, France
CHU Rennes - Hopital Pontchaillou

Rennes, ILE ET Vilaine, 35033, France
CHU de Liège

Liège, 4000, Belgium
CHU de Nantes-Hotel Dieu

Nantes, Loire Atlantique, 44093, France
Carol G Simon Cancer Center

Morristown, New Jersey, 07960, United States
Centre Henri Becquerel

Rouen, 76038, France
Centre Hospitalier Départemental Les Oudairies

La Roche-sur-Yon, Vendée, 85925, France
David H. Koch Center for Cancer Care

New York, New York, 10065, United States
Department of Medicine, Vejle Hospital

Vejle, South Region Denmark, 7100, Denmark
Duke University

Durham, North Carolina, 27710, United States
FH Hradec Kralove

Hradec Králové, Hradec Králové Region, 50005, Czechia
FH Ostrova

Ostrova, CZE, 70852, Czechia
Fakultni nemocnice Kralovske Vinohrady

Prague, 10034, Czechia
Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy
Fondazione Policlinico Universitario A. gemelli, IRCCS

Rome, Lazio, 00168, Italy
Fondazione del Piemonte per l'Oncologia IRCCS Candiolo

Candiolo, Torino, 10060, Italy
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Hackensack Meridian Health

Hackensack, New Jersey, 07601, United States
Hammersmith Hospital

London, Greater London, W12 0HS, United Kingdom
Horizon Health Network

Fredericton, New Brunswick, E3B 5N5, Canada
Hospital Clinic de Barcelona

Barcelona, Barcelona/Catalonia, 08034, Spain
Hospital Universitari Germans Trias i Pujol

Badalona, Barcelona, 08916, Spain
Hospital Universitario Fundacion Jimenez Diaz

Madrid, 28040, Spain
Hospital Universitario Marques de Valdecilla

Santander, Cantabria, 39008, Spain
Hospital Universitario del Vinalopó

Elche, Alicante, 3560, Spain
Indiana University Health Arnett, Inc.

Lafayette, Indiana, 47904, United States
Johns Hopkins Asthma & Allergy Center

Baltimore, Maryland, 21224, United States
Leicester Royal Infirmary

Leicester, Leicestershire, LE1 5WW, United Kingdom
MICS Centrum Medyczne Torun

Torun, Kuyavian-Pomeranian Voivodeship, 87100, Poland
Mayo Clinic - Jacksonville

Jacksonville, Florida, 32224, United States
McGill University Health Research Institute

Montreal, Quebec, H4A 3J1, Canada
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Montefiore Medical Center PRIME

The Bronx, New York, 10467, United States
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie-Panstwowy Instytut Badawczy

Gliwice, Sielesia, 44102, Poland
Ospedale San Raffaele

Milan, 20132, Italy
Ospedale di Circolo Fondazione Macchi

Varese, Lombardy, 21100, Italy
Penn State Hershey Medical Center

Hershey, Pennsylvania, 17033, United States
Pratia ES HLA Hospital Universitario Moncloa

Madrid, 28008, Spain
Pratia MCM Krakow

Krakow, Małopolska, 30224, Poland
Pratia Onkologia Katowice

Katowice, Silesian Voivodeship, 40519, Poland
Rigshospitalet

Copenhagen, 2100, Denmark
SSAK Partners

Coral Springs, Florida, 33065, United States
St Bartholomew's Hospital

London, EC1A 7BE, United Kingdom
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
UC Irvine

Orange, California, 92868, United States
UHKT Praha

Prague, 12800, Czechia
UZ Gent

Ghent, 9000, Belgium
Universitaetsklinikum Giessen und Marburg GmbH Standort Giessen

Giessen, Hesse, 35392, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz

Mainz, Rhineland-Palatinate, 55131, Germany
Universitair ziekenhuis Antwerpen UZA

Edegem, Antwerp, 2650, Belgium
University of Cincinnati Medical Center

Cincinnati, Ohio, 45219, United States
Vall d'Hebron Institut d'Oncologia

Barcelona, Catalonia, 08035, Spain
Zealand University Hospital

Roskilde, 4000, Denmark

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