Acute urate nephropathy

This pilot study tested whether a combination of phentermine and topiramate, two drugs used for weight loss, could help shrink uric acid kidney stones in obese people with type 2 diabetes or pre-diabetes. Nineteen participants were randomly assigned to receive the drug combo or c…

This study looked at whether losartan, a blood pressure medicine, can lower uric acid levels in children with proteinuric nephropathies (kidney disease with protein in urine). Forty children already taking enalapril were randomly assigned to receive either losartan or continue en…

This study tested whether the diabetes drug pioglitazone, weight loss, or both can help prevent uric acid kidney stones in overweight people. Twenty-nine participants were randomly assigned to one of three groups for 24 weeks. The main goal was to see if these interventions could…

This study tested a citrate mixture (citric acid, potassium bicarbonate, and sodium citrate) to dissolve coral-like urate kidney stones in 49 patients. The goal was to see if the treatment could shrink or eliminate stones, potentially avoiding surgery. Patients took a personalize…

This study tested a new wearable patch that collects sweat to measure sodium and creatinine levels, which are important for monitoring kidney health and dehydration. Five adults with kidney disease wore the patch while their sweat was analyzed using a special light-based techniqu…

This study looked at whether a common step in kidney stone surgery—placing a tube from the bladder to the kidney—can be skipped. 140 adults with large kidney stones were randomly assigned to get the standard surgery or a version without the tube. The goal was to see if the simple…