Acute tricyclic antidepressant poisoning
MONDO:0018547Acute tricyclic antidepressant (TCA) poisoning is a potentially lethal intoxication that is characterized by life-threatening arrhythmias (sinus tachycardias, premature ventricular contractions, ventricular arrhythmias), anticholinergic toxidrome (mydriasis, dry mucous membrane, tachycardia, hypertension), central nervous system toxicity (lethargy, coma, myoclonic jerks), refractory hypotension, and sudden death.
7 clinical trials for this condition and its sub-types.
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Can a common Alzheimer's drug prevent delirium relapse in poisoning patients?
Disease control TerminatedThis study tests whether rivastigmine, a drug used for Alzheimer's, can prevent delirium from coming back after initial treatment with physostigmine for anticholinergic poisoning. About 42 people aged 10 and older with controlled delirium will receive either rivastigmine or a pla…
Phase: PHASE2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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Massive study tests Blood-Cleaning therapy for poisoning victims
Disease control OngoingThis study looks at whether blood-filtering treatments, such as dialysis or plasma exchange, can help people survive acute poisoning. Researchers will compare over 5,000 poisoned patients who received these treatments with those who did not. The goal is to see if the treatments i…
Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School • Aim: Disease control
Last updated Jun 27, 2026 08:02 UTC
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Robot trainer aims to keep seniors on their feet during hospital stays
Disease control OngoingThis study tests whether robot-assisted leg exercises can prevent older patients from losing strength and independence during a hospital stay. 488 patients aged 65 and older will either receive robot-guided training or standard care. The goal is to see if the robot helps them wal…
Phase: NA • Sponsor: Odense University Hospital • Aim: Disease control
Last updated Jun 26, 2026 14:52 UTC