Acute tricyclic antidepressant poisoning

MONDO:0018547

Acute tricyclic antidepressant (TCA) poisoning is a potentially lethal intoxication that is characterized by life-threatening arrhythmias (sinus tachycardias, premature ventricular contractions, ventricular arrhythmias), anticholinergic toxidrome (mydriasis, dry mucous membrane, tachycardia, hypertension), central nervous system toxicity (lethargy, coma, myoclonic jerks), refractory hypotension, and sudden death.

7 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Poisoning (59) Acute disease (18) Human disease (14) Disease by etiologic mechanism (0) Disease of primarily extrinsic mechanism (0)

Trials to join now! 3 Not yet finished but already full! 3 Completed 1

Can a common drug reverse Poison-Induced delirium? new study says yes

Symptom relief Completed

This study tested whether rivastigmine can safely reverse delirium caused by poisoning from certain drugs like clozapine or tricyclic antidepressants. 100 patients at a poison center received rivastigmine, and doctors measured their consciousness and agitation levels. The goal wa…

Phase: PHASE4 • Sponsor: Alexandria University • Aim: Symptom relief

Last updated Jun 27, 2026 12:36 UTC

Acute tricyclic antidepressant poisoning

Broader categories

Can a common drug reverse Poison-Induced delirium? new study says yes