Acute liver failure
MONDO:0019542Rapid deterioration of liver function causing encephalopathy and coagulopathy. It results from damage to the liver parenchyma usually secondary to acetaminophen overdose or viral infections.
Also known as: acute hepatic failure, fulminant hepatic failure
27 clinical trials for this condition and its sub-types, 18 tagged with Acute liver failure itself.
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Browse by category →Sub-types of Acute liver failure
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Can a common antioxidant rescue failing livers?
Disease control Recruiting nowThis trial tests whether adding N-acetylcysteine (NAC) to standard care improves survival in adults with acute liver failure not caused by acetaminophen. Sixty-two patients will be randomly assigned to receive NAC or standard care alone. The study tracks survival at 28 days, hosp…
Sponsor: King Edward Medical University • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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Stem cell blood filter tested for liver failure
Disease control Recruiting nowThis early study tests whether using mesenchymal stem cells in a blood purification device is safe and can help adults with liver failure. Ten participants will receive the treatment alongside standard care. Researchers will track survival at 28 days and check for side effects. T…
Phase 1 • Sponsor: Kebo Zhong • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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New Blood-Cleaning machine could help liver failure patients avoid transplant
Disease control Recruiting nowThis study tests a combined blood-filtering system (DPMAS and plasma exchange) in 25 adults with acute-on-chronic liver failure who are either waiting for a liver transplant or not eligible for one. The goal is to see if this artificial liver support can keep patients alive witho…
Sponsor: Institute for Clinical and Experimental Medicine • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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Blood filtering showdown: can lower volume save young livers?
Disease control Recruiting nowThis study tests whether a standard volume of plasma exchange (blood filtering) works as well as a high volume in children aged 3 to 18 with acute liver failure. The goal is to see which approach helps more children survive without needing a liver transplant by day 21. Forty part…
Sponsor: Institute of Liver and Biliary Sciences, India • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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New injection shows promise for liver failure in early trial
Disease control Recruiting nowThis Phase 2 trial is testing an experimental drug called F573 in 97 people with acute liver failure or acute-on-chronic liver failure. Participants receive daily injections of F573 or a placebo for 7 days. The main goal is to check safety and side effects, while also looking at …
Phase 2 • Sponsor: Beijing Continent Pharmaceutical Co, Ltd. • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Sugar patterns in blood may foretell liver transplant rejection
Diagnosis Recruiting nowResearchers are testing whether a blood test that measures sugar chains on proteins can predict which liver transplant patients will lose their new organ or die within a year. The study enrolls 600 adults who are waiting for or have received a liver transplant. By analyzing blood…
Sponsor: University Hospital, Ghent • Aim: Diagnosis
Last updated Sep 21, 2026 23:00 UTC
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Massive european study aims to redefine success in liver transplants
Knowledge-focused Recruiting nowThis study is collecting information from 10,000 liver transplant patients across Europe to create a new, up-to-date reference for what good outcomes look like when using machine perfusion (a technique that keeps donated livers healthier before transplant). The goal is to help do…
Sponsor: University Medical Center Groningen • Aim: Knowledge-focused
Last updated Sep 21, 2026 23:00 UTC
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Massive registry launched to see if Blood-Filtering device helps sickest patients
Knowledge-focused Recruiting nowThis registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …
Sponsor: CytoSorbents, Inc • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:43 UTC