Acute leukemia
MONDO:0010643A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).
Also known as: acute leukaemia (disease), acute leukemia, acute leukemia (disease), leukemia, acute, X-linked, stem cell leukaemia, stem cell leukaemia (disease), stem cell leukemia, stem cell leukemia (disease)
4044 clinical trials for this condition and its sub-types, 124 tagged with Acute leukemia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Acute leukemia
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Acute lymphoblastic leukemia 508 trials · 1,319 incl. sub-types
12 sub-types
- B-cell chronic lymphocytic leukemia 509 trials · 538 incl. sub-types Sub-types →
- B-cell acute lymphoblastic leukemia 245 trials · 259 incl. sub-types Sub-types →
- Childhood acute lymphoblastic leukemia 96 trials · 136 incl. sub-types Sub-types →
- Precursor B-cell acute lymphoblastic leukemia 68 trials · 113 incl. sub-types Sub-types →
- T-cell acute lymphoblastic leukemia 75 trials · 104 incl. sub-types Sub-types →
- Acute biphenotypic leukemia 88 trials · 91 incl. sub-types Sub-types →
- Adult acute lymphoblastic leukemia 43 trials · 54 incl. sub-types Sub-types →
- Prolymphocytic leukemia 20 trials · 38 incl. sub-types Sub-types →
- Plasma cell leukemia 32 trials
- Lymphoblastic leukemia, acute, with lymphomatous features 7 trials
- Precursor T-cell acute lymphoblastic leukemia 4 trials
- Null-cell leukemia 0 trials
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Acute myeloid leukemia 1,098 trials · 1,194 incl. sub-types
78 sub-types
- Acute leukemia of ambiguous lineage 53 trials · 145 incl. sub-types Sub-types →
- Therapy related acute myeloid leukemia and myelodysplastic syndrome 87 trials · 88 incl. sub-types Sub-types →
- Acute myeloid leukemia by FAB classification 0 trials · 60 incl. sub-types Sub-types →
- Acute myeloid leukemia with multilineage dysplasia 34 trials
- Acute myeloid leukemia with mutated NPM1 25 trials
- Inherited acute myeloid leukemia 1 trial · 25 incl. sub-types Sub-types →
- Childhood acute myeloid leukemia 24 trials
- Acute myeloid leukemia, MLL gene rearrangement 23 trials
- Acute monocytic leukemia 20 trials Sub-types →
- Acute myeloid leukemia, FLT3 internal tandem duplication 18 trials
- Acute myeloid leukemia with 11q23 abnormalities 11 trials
- Acute myeloid leukemia, inv(16)(p13.1;q22) 10 trials
- Acute myeloid leukemia, t(16;16)(p13.1;q22) 10 trials
- Acute myeloid leukemia with BCR-ABL1 7 trials
- Acute myeloid leukemia with t(8;21)(q22;q22) translocation 7 trials
- Acute myeloid leukemia, del(5q31-q32) 5 trials
- Acute myeloid leukemia, t(8;21)(q22; q22.1) 5 trials
- Core binding factor acute myeloid leukemia 5 trials
- Acute myeloid leukemia with CEBPA somatic mutations 1 trial
- Acute myeloid leukemia with t(6;9)(p23;q34) 1 trial
- Acute myeloid leukemia, FLT3 tyrosine kinase domain point mutation 1 trial
- Acute myeloid leukemia, biallelic CEBPA gene mutation 1 trial
- Acute myeloid leukemia, t(15;17)(q24;q21) 1 trial
- Acute myeloid leukemia, t(v;11q23.3) 1 trial
- Acute myeloid leukemia with CBFA2T3-GLIS2 fusion 0 trials
- Acute myeloid leukemia with FUS-ERG fusion 0 trials
- Acute myeloid leukemia with MNX1-ETV6 fusion 0 trials
- Acute myeloid leukemia with NPM1 somatic mutations 0 trials
- Acute myeloid leukemia with NPM1-MLF1 fusion 0 trials
- Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 0 trials
- Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2) 0 trials
- Acute myeloid leukemia with t(8;16)(p11;p13) translocation 0 trials
- Acute myeloid leukemia with t(9;11)(p22;q23) 0 trials
- Acute myeloid leukemia, CEBPA gene mutation 0 trials
- Acute myeloid leukemia, GATA1 gene mutation 0 trials
- Acute myeloid leukemia, KIT exon 17 mutation 0 trials
- Acute myeloid leukemia, KIT exon 8 mutation 0 trials
- Acute myeloid leukemia, KIT gene mutation 0 trials
- Acute myeloid leukemia, KRAS gene mutation 0 trials
- Acute myeloid leukemia, Monosomy 5 0 trials
- Acute myeloid leukemia, Monosomy 7 0 trials
- Acute myeloid leukemia, NRAS gene mutation 0 trials
- Acute myeloid leukemia, Non-KMT2A MLLT10 rearrangement positive 0 trials
- Acute myeloid leukemia, PTPN11 gene mutation 0 trials
- Acute myeloid leukemia, RUNX1 gene mutation 0 trials
- Acute myeloid leukemia, Trisomy 8 0 trials
- Acute myeloid leukemia, WT1 gene mutation 0 trials
- Acute myeloid leukemia, del(13q14-q21) 0 trials
- Acute myeloid leukemia, der12p 0 trials
- Acute myeloid leukemia, inv(16)(p13.3;q24.3) 0 trials
- Acute myeloid leukemia, inv(3)(q21.3;q26.2) 0 trials
- Acute myeloid leukemia, loss of chromosome 17p 0 trials
- Acute myeloid leukemia, monoallelic CEBPA gene mutation 0 trials
- Acute myeloid leukemia, t(10;11)(p11.2;q23) 0 trials
- Acute myeloid leukemia, t(10;11)(p12;q23) 0 trials
- Acute myeloid leukemia, t(11;15)(p15;q35) 0 trials
- Acute myeloid leukemia, t(11;17) 0 trials
- Acute myeloid leukemia, t(11;19)(q23.3;p13.3) 0 trials
- Acute myeloid leukemia, t(11;19)(q23;p13) 0 trials
- Acute myeloid leukemia, t(11;19)(q23;p13.1) 0 trials
- Acute myeloid leukemia, t(16;21)(p11;q22) 0 trials
- Acute myeloid leukemia, t(16;21)(q24;q22) 0 trials
- Acute myeloid leukemia, t(1;11)(q21;q23) 0 trials
- Acute myeloid leukemia, t(1;22) 0 trials
- Acute myeloid leukemia, t(1;22)(p13;q13) 0 trials
- Acute myeloid leukemia, t(2;12) 0 trials
- Acute myeloid leukemia, t(3;12)(q23;p12.3) 0 trials
- Acute myeloid leukemia, t(3;3)(q21.3;q26.2) 0 trials
- Acute myeloid leukemia, t(3;5)(q25;q34) 0 trials
- Acute myeloid leukemia, t(4;11)(q21;q23) 0 trials
- Acute myeloid leukemia, t(5;11)(q35;p15) 0 trials
- Acute myeloid leukemia, t(6;11)(q27;q23) 0 trials
- Acute myeloid leukemia, t(6;9)(p23;q34.1) 0 trials
- Acute myeloid leukemia, t(7;12)(q36;p13) 0 trials
- Acute myeloid leukemia, t(8;16) 0 trials
- Acute myeloid leukemia, t(9;11)(p21.3;q23.3) 0 trials
- Acute myeloid leukemia, t(9;22)(q34.1;q11.2) 0 trials
- Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13) 0 trials
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Leukemia, acute, X-linked 0 trials
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Subacute leukemia 0 trials
Most studied deeper sub-types
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Vaccine aims to train immune system against blood cancers
Vaccine CompletedResearchers are testing a vaccine called 3D189 in adults with blood cancers such as acute leukemia, multiple myeloma, non-Hodgkin lymphoma, and higher-risk myelodysplastic syndrome. Participants must be in remission after standard treatment and unable to receive a stem cell trans…
Phase 1 • Sponsor: 3D Medicines • Aim: Vaccine
Last updated Sep 11, 2026 00:00 UTC
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Dietary change may curb recurrent c. diff in cancer patients
Disease control CompletedThis study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…
Sponsor: University of Colorado, Denver • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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New cord blood matching method could expand transplant access for blood cancer patients
Disease control CompletedThis study tests a new approach to stem cell transplants for people with blood cancers like leukemia and lymphoma. Patients receive a combination of umbilical cord blood and stem cells from a family member, with the cord blood chosen based on specific genetic markers rather than …
Phase 2 • Sponsor: Weill Medical College of Cornell University • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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New drug combo may make cord blood transplants safer for blood cancer patients
Disease control CompletedThis study tested whether adding the drug tocilizumab to standard care could reduce the risk of graft-versus-host disease (GVHD) after a cord blood transplant in adults with blood cancers. GVHD is a serious complication where donor cells attack the patient's body. Tocilizumab blo…
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Could a cancer drug fix an irregular heartbeat?
Disease control CompletedThis study looked at whether Vidaza, a drug used for acute leukemia, could also help treat atrial fibrillation (an irregular heartbeat). The idea was that Vidaza might reverse certain DNA changes that lower the activity of a gene important for heart function. Only one person took…
Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New Two-Step transplant shows promise for blood cancer patients
Disease control CompletedThis study tested a two-step stem cell transplant for people with blood cancers like leukemia and lymphoma. First, patients received low-dose chemotherapy and radiation to prepare their bodies. Then, they got donor stem cells followed by drugs to prevent the donor cells from atta…
Phase 2 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New drug combo aims to tame deadly transplant complication
Disease control CompletedThis phase II trial tested whether adding the drug itacitinib to standard medications (tacrolimus and sirolimus) can better prevent graft-versus-host disease (GVHD) in 59 patients with blood cancers receiving donor stem cell transplants. GVHD occurs when donor immune cells attack…
Phase 2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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New Two-Step transplant shows promise for tough blood cancers
Disease control CompletedThis phase 2 trial tested a two-step stem cell transplant approach for 47 patients with high-risk blood cancers like leukemia and lymphoma. The method uses the drug cyclophosphamide to lower the chance of graft-versus-host disease (GVHD), a common complication. The goal was to se…
Phase 2 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Supercharged cord blood transplant shows promise in blood cancer trial
Disease control CompletedThis Phase 3 trial tested a special cord blood product called NiCord (omidubicel) against standard cord blood transplants in 125 people with blood cancers like leukemia and lymphoma. The goal was to see if NiCord helps the body rebuild its infection-fighting cells faster. Researc…
Phase 3 • Sponsor: Gamida Cell ltd • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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New antibody drug tested in patients with relapsed blood cancers
Disease control CompletedThis early-stage trial tested the safety and best dose of flotetuzumab, an antibody drug, in 13 patients with advanced blood cancers that had come back or stopped responding to treatment. The drug works by blocking cancer cell growth. The main goal was to see what side effects oc…
Phase 1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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New combo therapy aims to tame stem cell transplant complications
Disease control CompletedThis study tested a new drug called VIC-1911 added to standard medications to prevent graft-versus-host disease (GVHD) in 16 adults with blood cancers receiving a stem cell transplant. The goal was to find a safe and effective dose that reduces GVHD and relapse. Results are still…
Phase 1/2 • Sponsor: Masonic Cancer Center, University of Minnesota • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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New drug may reduce transplant complications in blood cancer patients
Disease control CompletedThis study tested whether the drug palifermin could make stem cell transplants safer and reduce chronic graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. Thirty-four adults with blood cancers received palifermin before transplan…
Phase 1/2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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New ultrasound could spot heart trouble before It's too late for chemo patients
Diagnosis CompletedThis study tested whether a special heart ultrasound (2D strain imaging) can detect early signs of heart damage caused by anthracycline chemotherapy in 100 leukemia patients. The goal is to catch problems sooner, so doctors can adjust treatment and reduce the risk of permanent he…
Sponsor: University Hospital, Bordeaux • Aim: Diagnosis
Last updated Jun 27, 2026 12:39 UTC
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New shot may shield transplant patients from deadly immune attack
Prevention CompletedThis study tested a drug called abatacept, given as a shot under the skin, to prevent a serious complication called graft-versus-host disease (GVHD) in 29 adults with blood cancers. Participants received a stem cell transplant from a half-matched donor. The goal was to see if aba…
Phase 1/2 • Sponsor: The First Affiliated Hospital of Soochow University • Aim: Prevention
Last updated Jun 27, 2026 13:06 UTC
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New antibiotic may replace standard infection prevention in blood cancer patients
Prevention CompletedThis study tested whether fosfomycin, an older antibiotic, works as well as ciprofloxacin for preventing serious infections in people with blood cancers like leukemia or those receiving a stem cell transplant. 177 adults from 11 Spanish hospitals took part. The main goal was to s…
Phase 3 • Sponsor: Fundación para la Investigación Biosanitaria del Principado de Asturias • Aim: Prevention
Last updated Jun 27, 2026 13:01 UTC
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Fencing fights fatigue: new program aims to keep blood cancer patients moving
Symptom relief CompletedThis study tested whether a fencing-based exercise program is practical for adults with leukemia or lymphoma who are receiving intensive treatment in a hospital. The goal was to reduce physical decline caused by long bed rest. Eighty patients were invited to take part, and resear…
Sponsor: University Hospital, Angers • Aim: Symptom relief
Last updated Jun 27, 2026 12:39 UTC
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Beauty sessions may ease anxiety for blood cancer patients in isolation
Symptom relief CompletedThis study tested whether aesthetic therapy sessions (like skincare or makeup) could reduce anxiety and improve quality of life for patients with acute leukemia or those who had a stem cell transplant. These patients are isolated in a protected hospital area for at least 28 days.…
Sponsor: University Hospital, Lille • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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Can early palliative care ease suffering in relapsed leukemia?
Symptom relief CompletedThis study looked at whether early, regular visits from a palliative care team can improve quality of life for adults with acute leukemia that has returned. 49 patients were assigned to either receive this extra support or standard care. The team addressed physical, emotional, an…
Sponsor: Hospices Civils de Lyon • Aim: Symptom relief
Last updated Jun 26, 2026 16:57 UTC
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Could a platelet-boosting drug shorten recovery after stem cell transplants?
Knowledge-focused CompletedThis study looks back at medical records of people who had an allogeneic stem cell transplant to see whether romiplostim helped their platelets recover faster. Platelets are blood cells that help clotting, and low counts are common after transplant. The researchers will compare p…
Sponsor: Tongji Hospital • Aim: Knowledge-focused
Last updated Aug 07, 2026 00:00 UTC
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New dashboard aims to make leukemia trials more inclusive
Knowledge-focused CompletedThis study tests a data visualization tool called the Trial Enrollment Diversity Dashboard (TEDD) designed to help doctors see how diverse their clinical trial enrollments are. The goal is to overcome racial and ethnic disparities in leukemia trial participation. The study enroll…
Sponsor: Dana-Farber Cancer Institute • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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Stem cell transplant leaves many women with hidden gynecological issues
Knowledge-focused CompletedThis study looked at 51 women who had a stem cell transplant for acute leukemia as adults. Researchers wanted to find out how many had gynecological problems like early menopause, vaginal graft-versus-host disease, or cervical issues two years after transplant. They also checked …
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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New study tracks immune cell function after stem cell transplants to personalize care
Knowledge-focused CompletedThis completed study looked at how immune cells recover in 61 adults who received a stem cell transplant for blood cancers. Researchers measured the function of T and NK cells by testing their cytokine profiles after stimulation. The goal was to see if these measurements could he…
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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Scientists hunt for hidden signs in blood cancers to personalize treatment
Knowledge-focused CompletedThis study collected blood, bone marrow, skin, and cheek cell samples from 650 adults with acute leukemia, myelodysplastic syndromes, or myeloproliferative disorders. Researchers analyzed the samples to find genetic, epigenetic, and drug sensitivity patterns that might predict ho…
Sponsor: Institut Paoli-Calmettes • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Leukemia Patients' clotting proteins under the microscope
Knowledge-focused CompletedThis study looked at levels of certain blood clotting proteins (antithrombin III, protein C, protein S, and D-dimer) in 60 people with acute leukemia and compared them to 30 healthy volunteers. The goal was to see if these proteins are different in leukemia patients. No treatment…
Sponsor: Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Blood samples may reveal how to stop transplant complications
Knowledge-focused CompletedThis completed study involved 146 patients with blood cancers who received a stem cell transplant from a donor. Researchers collected blood and tissue samples over a year to study immune cells linked to graft-versus-host disease (GVHD), a common complication where donor cells att…
Sponsor: Asan Medical Center • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:53 UTC