Achalasia
MONDO:0008698A finding indicating the lack of adequate relaxation of the lower esophageal sphincter resulting in difficulty swallowing food.
Also known as: achalasia, achalasia (disease), achalasia of cardia, achalasia of oesophagus, cardiospasm, esophageal achalasia
48 clinical trials for this condition and its sub-types, 35 tagged with Achalasia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Achalasia
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Idiopathic achalasia 12 trials
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Achalasia, familial esophageal 0 trials
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Shorter surgery may be just as effective for treating achalasia
Disease control Not yet recruitingThis trial tests whether a shorter muscle cut during a procedure called POEM works as well as a longer one for people with type II achalasia, a condition where the esophagus fails to push food into the stomach. Fifty participants will be randomly assigned to receive either a shor…
Sponsor: Assiut University • Aim: Disease control
Last updated Jul 09, 2026 00:00 UTC
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Disposable scope could make gut surgery safer
Disease control Not yet recruitingThis pilot trial will test a disposable endoscope in 40 adults undergoing POEM procedures for achalasia or gastroparesis. The goal is to see if the single-use scope works as well as standard reusable scopes, potentially reducing infection risk. All participants receive standard c…
Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Smarter surgery may cut reflux after achalasia procedure
Disease control Not yet recruitingThis study compares two versions of a minimally invasive procedure called POEM for treating achalasia, a swallowing disorder. The standard POEM often causes severe heartburn afterward. The new version, Sling-Fiber Preserving POEM, aims to reduce that risk by leaving certain stoma…
Sponsor: University of California, Irvine • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Through-the-Mouth surgery vs keyhole surgery: which works better for a rare swallowing disorder?
Symptom relief Not yet recruitingAchalasia makes it hard to swallow because the valve between the esophagus and stomach stays tight. Researchers randomly assign 220 adults with newly diagnosed achalasia to two procedures that cut that valve muscle: POEM, done through the mouth with no skin cuts, or laparoscopic …
Sponsor: Minia University • Aim: Symptom relief
Last updated Sep 12, 2026 00:00 UTC
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Cutting across or along? trial tests best way to start POEM for swallowing disorder
Symptom relief Not yet recruitingThis trial tests whether making a horizontal (transverse) or vertical (longitudinal) cut in the esophagus lining during POEM surgery is faster and safer for people with achalasia, a swallowing disorder. About 140 adults in Colombia will be randomly assigned to one of the two inci…
Phase 3 • Sponsor: Universidad Nacional de Colombia • Aim: Symptom relief
Last updated Jun 27, 2026 09:07 UTC
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New study tests best timing for achalasia procedure
Symptom relief Not yet recruitingThis study looks at a procedure called POEM for people with achalasia, a condition where the esophagus has trouble moving food to the stomach. It compares patients getting POEM as their first treatment versus those who had a previous balloon dilation that didn't work well. Resear…
Sponsor: Assiut University • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Weight gain after swallowing treatment may raise health risks
Knowledge-focused Not yet recruitingThis study follows 30 people with achalasia (a swallowing disorder) for one year after their treatment. Researchers want to see if the weight gain that often happens after treatment leads to worse metabolic health, like fatty liver or higher blood sugar. Participants will have bl…
Sponsor: Assaf-Harofeh Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC