Abdominal wall malformation

This study looks at whether delivering babies with gastroschisis at 35 weeks is better than waiting until 38 weeks. Gastroschisis is a birth defect where the baby's intestines stick out of a hole in the belly. The study will track 300 pregnant people and compare risks like stillb…

This study tests whether feeding babies with congenital gastrointestinal issues (like gastroschisis or Hirschsprung disease) only human milk helps them reach full feeds faster than standard care, which may include formula. Researchers will also look at gut bacteria and infection …

This trial tests a new fetal surgery to repair complex gastroschisis, a birth defect where the baby's intestines stick out of the belly. Ten pregnant women will undergo a fetoscopic procedure to reduce the bowel and close the skin. The goal is to see if this approach is safe and …

This study looks at whether it is possible to start feeding breast milk early to newborns with gastroschisis, a condition where the intestines are outside the belly at birth. The goal is to see if parents agree to join the study and if doctors can follow the early feeding plan. T…

This study tests if transplanting a piece of abdominal wall (the muscle and tissue covering the belly) can safely repair large defects, like hernias or injuries. It can be done alone or with another organ transplant, like a kidney or liver. Only 5 adults aged 18-65 are being enro…

This study tests whether eating a diet very low in polyamines (natural compounds found in many foods) for a week before and after major abdominal surgery can lower pain levels. Researchers will compare pain scores and painkiller use in 278 adults who either follow the special die…

This study looks at DNA methylation patterns (chemical tags on DNA) in fetuses with rare genetic diseases. Researchers will analyze DNA from amniotic fluid and tissue samples to create reference signatures. The goal is to improve diagnosis of these conditions before birth. The st…

This study is testing a new, non-invasive monitor (fetal magnetocardiography) to detect hidden heart problems in high-risk pregnancies that might lead to fetal death. Researchers will study 30 pregnant women with conditions like congenital heart disease or twin pregnancy. The goa…

This study tests whether giving extra arginine (a nutrient) to preterm and full-term infants after major bowel surgery or a serious gut infection (necrotising enterocolitis) can improve their immune function. Researchers will measure changes in gene activity related to infection-…

This study measures two natural amino acids, arginine and ADMA, in newborns who had abdominal surgery within their first 5 days of life. Researchers want to see if the balance of these substances can help predict how quickly a baby recovers and whether complications arise. No ext…

This study is testing whether using rapid genetic sequencing can help doctors diagnose and treat birth defects in newborns in intensive care. Researchers will enroll 2,000 babies and compare death rates, disability rates, and genetic findings. The goal is to see if personalized t…