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127005 trials found · Page 5705 of 6351
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New hip implant put to the test: will it stay put?
Knowledge-focused OngoingThis study aims to evaluate long term fixation of the Mpact Double Mobility cup trough IMAGIKA technology.
Sponsor: Medacta International SA • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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Blood marker may predict prostate cancer drug response
Knowledge-focused Stopped earlyThe purpose of this study is to investigate cleavage products of the urokinase plasminogenactivator receptor (uPAR) in plasma from patients with castration resistant prostate cancer as a predictive marker of response to abiraterone.
Sponsor: Kristoffer Rohrberg • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Trauma's hidden toll: stem cell failure may explain slow recovery in elderly
Knowledge-focused Recruiting nowTraumatic injury is a leading cause of morbidity and mortality in young adults, and remains a substantial economic and health care burden. Despite decades of promising preclinical and clinical investigations in trauma, investigators understanding of these entities is still incomp…
Sponsor: University of Florida • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Routine CT scan after pancreatic surgery may catch silent complications
Knowledge-focused CompletedPancreatectomy represents the classic approach for resectable lesions of the pancreas, duodenum and periampullary region. Due to the technical skills required, the complex anatomy and the extreme fragility of the pancreatic parenchyma, pancreatic resection is still considered to …
Sponsor: CHU de Reims • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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DNA registry aims to unlock secrets of testicular cancer
Knowledge-focused Recruiting nowThis study is being done to create a registry to help us learn more about germ cell tumors (GCT) and other testicular tumors. The registry will include people with these tumors and also relatives and unrelated people without these tumors. This study will help us learn more about …
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Scientists track heart changes after attack to predict failure risk
Knowledge-focused OngoingTo comprehensively characterize Left Ventricular (LV) remodeling after Myocardial Infarction (MI) in the community, study the association between patterns of remodeling and biological pathways and examine the association between the predictors of remodeling and heart failure afte…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Ketamine may help ICU patients breathe easier on ventilators
Knowledge-focused CompletedImpairment of airway patency is a common cause of extubation failure and opioids and hypnotics can adversely affect airway patency. Ketamine, a noncompetitive antagonist of N-methyl-D-aspartate (NMDA), unlike other anesthetics activates respiratory effort and promotes bronchodila…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Massive study aims to settle best surgery for deadly aortic tear
Knowledge-focused By invitation onlyAcute Stanford type A aortic dissection (TAAD) is a life-threatening clinical status requiring surgery that is usually performed as a salvage procedure.We planned a multicenter study to evaluate the balance between the patient's condition and those therapeutic strategies that may…
Sponsor: Centre Cardiologique du Nord • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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Jawbone graft showdown: which technique works best for dental implants?
Knowledge-focused CompletedHorizontal alveolar ridge deficiencies may prevent the placement of dental implants and often require bone augmentation procedures before implant treatment. Two techniques commonly used for horizontal ridge augmentation are the Split Box Technique and the Split Bone Block Techniq…
Sponsor: Marmara University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Could a tiny surgical patch preserve your voice after thyroid removal?
Symptom relief CompletedThis randomized controlled trial evaluated whether placement of oxidized regenerated cellulose (ORC) over the recurrent laryngeal nerves during total thyroidectomy affects early postoperative voice quality. Patients undergoing bilateral total thyroidectomy for benign or malignant…
Sponsor: Ankara University • Aim: Symptom relief
Last updated Jul 04, 2026 00:00 UTC
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Narcoleptic Kids' weight gain mystery: is metabolism to blame?
Knowledge-focused CompletedA significant weight gain and obesity are observed for most patients with narcolepsy, mainly at the beginning of the disease and narcolepsy in young children. There is no specific study on the population and the consequences of overweight in the lives of these long-term patients.…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Heart Infection's hidden brain damage tracked over time
Knowledge-focused CompletedPrimary objective: To describe the evolution of cerebral lesions in IE patients (number of patients with abnormal cerebral MRI in acute phase of IE and during follow-up).
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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Can a simple numbing gel ease skin graft pain?
Symptom relief CompletedThe aim of the study is to Evaluate of the analgesic effect of ropivacaine in topical use at the thin skin graft donor site. For Patient needing a thin skin graft \< 320 cm2, randomization will be done in 2 groups, one receiving the standard treatment (20 mL of physiologic serum…
Phase 3 • Sponsor: University Hospital, Rouen • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Scientists probe Inflammation's role in heart disease and diabetes
Knowledge-focused CompletedBackground: \- Cardiometabolic diseases are a combination of medical disorders that, when they occur together, increase the risk of heart disease and diabetes. Researchers want to learn if there is a relationship between these diseases and inflammation (redness, swelling, and pa…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Aug 20, 2026 00:00 UTC
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Teen suicide gene hunt: can DNA predict risk?
Knowledge-focused CompletedSuicidal behaviors is known to aggregate in families. The purpose of this study is to evaluate association between common polymorphisms in genes important for neurobiological pathways linked to suicidal behaviors and suicide attempt among adolescents patient.
Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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New drug combo tested for tough pancreatic cancer
Disease control CompletedThe study's overall objectives are to evaluate the safety of anakinra in combination with standard chemotherapy regimens in patients with pancreatic ductal adenocarinoma, as well as to collect preliminary immune modulation and clinical activity information, overall survival, and …
Phase 1 • Sponsor: Baylor Research Institute • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Hidden liver harm: study tracks silent damage in genetic disorder
Knowledge-focused OngoingThe investigators hypothesize that there is liver injury (inflammation, fibrosis, cirrhosis) in adults with Alpha-1 Antitrypsin Deficiency (AATD), which is asymptomatic, under-recognized, and undiagnosed. In addition, the investigators believe that the genetic and environmental f…
Sponsor: St. Louis University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Blood marker study aims to predict preterm birth risk
Knowledge-focused Stopped earlyAmong all patients hospitalized for Threatened Premature Delivery (TPD), the rate of premature birth (PB) before 37 weeks is about 42%, which reflects the inability to accurately identify patients at high risk of PB. Currently, no clinical or biological marker is recognized as th…
Sponsor: Centre Hospitalier Departemental Vendee • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Can a stomach biopsy predict who will respond to gastric pacemakers?
Knowledge-focused Recruiting nowIn this research study, biopsy samples will be collected to provide more insight into the underlying cause of the motility disorders, help direct further investigation into the cause of the underlying condition, provide future prognosis and predict response to gastric electrical …
Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New bandage aims to speed up healing of painful tailbone cysts
Symptom relief CompletedSinus pilonidal concern 26/100 000 young adults. It manifests after puberty, presenting as an acute abscess in approximately 50% of patients or as a discharging painful sinus. Patients may experience lengthy healing times resulting in considerable morbidity and disruption to a yo…
Sponsor: University Hospital, Strasbourg, France • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC