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116076 trials found · Page 5141 of 5804
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New monitoring method may help doctors manage blood pressure during heart surgery
Knowledge-focused CompletedCentral and peripheral arterial pressure decoupling occurs in some clinical conditions like sepsis or cardiopulmonary bypass. This decoupling may leed to unsuitable decisions such as the use of catecholamines. The aim of this study is to evaluate the pulse wave's speed as a mark…
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:01 UTC
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Sniffing out clues: smell tests may reveal brain secrets in bipolar disorder
Knowledge-focused CompletedTo compare olfactory performance between patients with BD and HC and correlate their performances to neuroimaging data
Phase: NA • Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:36 UTC
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Hidden danger: blood clot prevention device may cause pressure sores
Knowledge-focused CompletedPressure sores, also known as pressure ulcers, are a significant complication among hospitalized patients, particularly those who are immobile or require prolonged care. Intermittent pneumatic compression (IPC) devices are routinely used to prevent deep vein thrombosis (DVT); how…
Sponsor: Assuta Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Fish oil for moms: could a simple supplement reduce stress and boost baby development?
Knowledge-focused OngoingThe purpose of the study is to test whether nutritional supplementation during pregnancy is associated with 1) improved maternal health during pregnancy; 2) improved infant birth and neurodevelopmental outcomes, and 3) whether the association between nutritional supplementation d…
Phase: NA • Sponsor: University of Chicago • Aim: Knowledge-focused
Last updated Jul 19, 2026 00:00 UTC
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Fall risk calculator could save lives by predicting who needs urgent care
Knowledge-focused CompletedThis retrospective, multicenter, registry-based cohort study used data from the Pan-Asian Trauma Outcomes Study registry between January 2016 and December 2024. Adult patients with fall-related trauma were included if they had available data on age, sex, emergency department vita…
Sponsor: Mackay Memorial Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Smartwatches and video calls could ease cancer care for rural patients
Symptom relief CompletedObservational study about patients treated for a metastasis breast cancer who live far from their comprehensive cancer center and followed by telemedicine, connected watches and patient-reported symptom monitoring.
Sponsor: Institut Bergonié • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Mineral baths may affect heart health in osteoarthritis patients
Knowledge-focused CompletedThis prospective observational study aims to evaluate changes in heart function using echocardiography before and after a standardized balneotherapy program in adult and elderly patients with osteoarthritis. Balneotherapy is commonly used by patients with osteoarthritis, especia…
Sponsor: Bursa City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Heart wire removal procedure analyzed in 702 patients
Knowledge-focused CompletedThe number of devices for cardiac pacing and defibrillation has increased in recent years. However, although they have improved in terms of quality and extended lifespan after implantation, they are not free from complications. The Achilles' heel of cardiac implantable electronic…
Sponsor: Medical University of Silesia • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC
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Scientists hunt for early warning signs of arthritis in joint fluid
Knowledge-focused OngoingOsteoarthritis is a condition that causes joints in the human body to deteriorate over time. This condition affects more than 250 million people around the globe. Currently, the goal of treating osteoarthritis involves reducing the severity and pain that results from the disease.…
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Morning or afternoon? new study tests best time for heart surgery
Knowledge-focused CompletedThis study aims to understand the impact of time-of-the day on human myocardial tolerance to ischemia-reperfusion by exploring atrial myocardium biopsied during cardiac surgery. Patients scheduled for non-urgent cardiac surgery (coronary artery by-pas graft and/or aortic valve re…
Phase: NA • Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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10,000 patients join hunt to tame deadly inflammation after aortic tear
Knowledge-focused Recruiting nowAcute aortic syndrome (AAS) is a life-threatening condition. Inflammation plays a key role in the pathogenesis, development and progression of AAS, and is associated with significant mortality and morbidity. Understanding the inflammatory responses and inflammation resolutions is…
Sponsor: Nanjing Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Can a simple valve help tracheostomy patients sleep better and safer?
Symptom relief CompletedLimited research has been done to assess the safety of PMV use during sleep. One prospective study completed by Diez-Gross, et al in 2007 looked at 10 male subjects recorded on two consecutive nights, one night with PMV on and one night with PMV off. All recordings took place in …
Phase: NA • Sponsor: Gaylord Hospital, Inc • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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New study aims to unravel balance secrets in spine patients
Knowledge-focused Recruiting nowA good understanding of the principles of balance is vital to achieve optimal outcomes when treating spinal disorders. A complex interaction of the neuromotor system and muscular recruitment is necessary for ergonomic balance and deliberate displacement of the human body. Sagitta…
Phase: NA • Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Tiny study probes rare pancreatitis after clot removal
Knowledge-focused Recruiting nowAcute pancreatitis is a rare complication after percutaneous mechanical thrombectomy in treatment of thrombotic disorders. The objectives of this study include: (1) Determine the incidence and severity of acute pancreatitis after percutaneous mechanical thrombectomy; (2) Identify…
Sponsor: RenJi Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Which rectal cancer treatment leads to better surgery outcomes?
Knowledge-focused CompletedAim: We evaluated the surgical outcomes of 3 groups of patients with rectal cancers - RAPIDO vs standard long course radiotherapy (LCRT) vs upfront surgery to objectively determine the effects of TNT on TME. Methods: A review of prospectively collected data was performed for pat…
Sponsor: Sengkang General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:26 UTC
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Million-Patient study questions Pre-Surgery fasting rules
Knowledge-focused Recruiting nowPerioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful. This study intends to characterize perioperative fasting practices and their potential effects on c…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Could antibodies be behind POTS? new study investigates
Knowledge-focused Recruiting nowObjective: In this pilot study, we will test the hypothesis that patients with POTS (age 18-60 years) will have a higher percentage of functional antibodies to adrenergic receptors compared with control subjects without POTS.
Sponsor: University of Calgary • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Weight loss surgery may shield kidneys in obese patients
Knowledge-focused CompletedObesity promotes chronic kidney disease and is accelerating its shift to the stage of renal replacement. Bariatric surgery is a treatment for severe or morbid obesity whose renal benefit is currently unknown. The glomerular filtration rate (GFR) is the best parameter to define th…
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Scientists try out new tools to feel how hard tumors are
Knowledge-focused CompletedThis trial studies how well a Millar Mikro-tip catheter and shear wave elastography measure pressure and stiffness inside tumors among patients with solid tumors undergoing an ultrasound-guided biopsy. A Millar Mikro-tip catheter measures the pressure inside the tumor. Shear wave…
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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Gene hunt: why does sunitinib work differently in kidney cancer patients?
Knowledge-focused CompletedThe primary objective of this study is to determine the percentage of patients with a plasma concentration of sunitinib remaining at equilibrium (\[Suni\]REq) greater than 100 ng / ml (effective concentration according to the current literature).
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC