Experimental lung cancer combo trial halted early
NCT ID NCT05815160
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tested an experimental drug called Debio 0123 combined with standard chemotherapy (carboplatin and etoposide) in 34 adults with small cell lung cancer that had returned after prior treatment. The main goal was to find a safe dose and check for side effects. The study was terminated, so full results are not available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Debio 0123 (an experimental drug) combined with carboplatin and etoposide (standard chemotherapy)
- What this could lead to
- If it works, this could point toward a new treatment option for people with small cell lung cancer that has come back after standard therapy.
- What could go wrong
- This is a very early (Phase 1) trial that was terminated, so results are limited. The combination may not prove safe or effective in larger studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Clinica Universidad de Navarra
Madrid, 28027, Spain
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Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
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Hospital Quironsalud Malaga
Málaga, 29004, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario HM Sanchinarro. START Madrid - Centro Integral Oncológico Clara Campal (CIOCC)
Madrid, 28050, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario de A Coruna
A Coruña, 15006, Spain
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Institut Catala D'Oncologia - Badalona
Barcelona, 08908, Spain
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NEXT Oncology Madrid
Madrid, 28223, Spain
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Roswell Park Comprehensive Cancer Center
Buffalo, New York, 14263, United States