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127005 trials found · Page 2562 of 6351
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Could a routine pregnancy vaccine influence breastfeeding and baby health? a massive study digs into the data.
Knowledge-focused CompletedA retrospective cohort study based on the secondary use of pre-existing data. The study assesses the association between antenatal and postpartum maternal Tdap vaccination and select infant and lactation-related outcomes.
Sponsor: HealthPartners Institute • Aim: Knowledge-focused
Last updated Aug 01, 2026 00:00 UTC
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Surgery offers new hope for chronic pain sufferers
Symptom relief CompletedThis clinical study evaluates the effectiveness of surgical treatment in patients with upper-limb complex regional pain syndrome (CRPS) diagnosed according to the Budapest criteria. Seventy-four patients were assessed between 2014 and 2023. Patients with identifiable structural p…
Sponsor: Jitka Fricova • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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New balloon treatment for heart disease under Real-World study
Disease control Recruiting nowThe purpose of this study is to evaluate long-term effectiveness and safety of patients with coronary disease treated with drug eluting balloon in real world practice.
Sponsor: Seung-Jung Park • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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New tube system could make dialysis access easier for kidney patients
Disease control CompletedThe objective of this study is to evaluate the safety and efficacy of the FLEX System when used to create an arteriovenous fistula (AVF or AV fistula) percutaneously in patients with Chronic Kidney Disease (CKD) who require hemodialysis vascular access.
Sponsor: C. R. Bard • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Which radiation boost is better for prostate cancer? new trial aims to find out
Disease control OngoingOptimal non surgical treatment of prostate cancer requires dose escalation which is frequently provided by adding a brachytherapy "boost" to a short course of external beam radiotherapy. The hypothesis in this randomized study is that a High Dose Rate (HDR) brachytherapy boost le…
Sponsor: British Columbia Cancer Agency • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Can a calming drug combo bring clarity to cancer patients?
Symptom relief OngoingThis randomized phase II trial studies how well haloperidol with or without lorazepam works in reducing confusion, disorientation, and inability to think or remember clearly (delirium) in patients with cancer that has spread to other places in the body and usually cannot be cured…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jul 19, 2026 00:00 UTC
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New drug cuts chemotherapy side effect by over 60% in breast cancer patients
Disease control CompletedThe goal of this clinical trial is to learn if Naderin works to prevent low white blood cell counts in people with breast cancer receiving first-line chemotherapy. The main questions it aims to answer are: 1. Does taking Naderin lower the number of people who get low white blood…
Phase 2/3 • Sponsor: MIPO Clinic • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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Coordinated care after a fracture could stop the next one
Disease control OngoingAims: to Establish the FLS services at the National Taiwan University Hospital (NTUH) and its Beihu Branch (BB). Method: From Jan., 2014, two related fracture liaison services (FLSs) following the 13 'Capture the Fracture Best Practice Standards' were implemented at the National…
Sponsor: National Taiwan University Hospital • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Built-In eye scanner could give surgeons a live 3D view during operations
Knowledge-focused CompletedOptical coherence tomography (OCT )provides high resolution information regarding the anatomic structure of the tissues of the eye in a cross-sectional and 3 dimensional view. Much of this information is not able to be visualized by a clinician. Utilizing this information during …
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC
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New PET scan may sharpen radiation targeting for brain cancer patients
Knowledge-focused CompletedThis phase II trial studies how well fluorine F 18 fluorodopa (18F-DOPA)-positron emission tomography (PET) works in finding tumors in patients with newly diagnosed gliomas undergoing radiation therapy. Comparing results of diagnostic procedures done before and during radiation t…
Phase 2 • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC
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Massive study aims to perfect testicular cancer aftercare
Knowledge-focused Recruiting nowThe majority of testicular cancer patients can be cured with cisplatin-based chemotherapy. Mortality has been reduced even more within the last 15 years due to the stringent application of standard chemotherapy followed by resection of residual disease. This is a positive develop…
Sponsor: Dr. med. Christian Rothermundt • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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Does practice make perfect? a study probes how a Surgeon's learning curve impacts cancer surgery success
Knowledge-focused CompletedBased on the data analysis of the General Surgery Department (Northern Department) of Ruijin Hospital from December 2013 to June 2021, we conducted a retrospective cohort study. Multivariate risk-adjusted cumulative sum analysis (RA-CUSUM) was used to evaluate the learning curve …
Sponsor: Ruijin Hospital • Aim: Knowledge-focused
Last updated Aug 01, 2026 00:00 UTC
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Tailored chemo regimens tested for frail ovarian cancer patients
Disease control CompletedThe current standard of first-line chemotherapy in advanced ovarian cancer is the combination of carboplatin AUC 5mg/mL/min and paclitaxel 175 mg.m-². This combination is feasible in selected elderly patients such as those included in prospective trials. These trials, however, in…
Phase 2 • Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Can we predict who will thrive with brain stimulation for Parkinson's?
Knowledge-focused CompletedThis study identify preoperative predictors of response to subthalamic stimulation at 1 year, 3 years and 5 years in terms of quality of life, from a broad prospective multicenter study French with standardized collection of clinical data , imaging and genetic . The investigator…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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New knee implant tracked for 5 years in 777 patients
Disease control OngoingThe primary objective of this study is to obtain implant survivorship and clinical outcomes data for commercially available Persona knee implants used in primary total knee arthroplasty. The assessment will include: 1. Implant survivorship based on removal of a study device. 2. …
Sponsor: Zimmer, GmbH • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Brain scan breakthrough: new MRI method could spot autism in kids
Diagnosis CompletedThe purpose of this study is reproduce the individual detection results by PET with Arterial Spin Labeling (ASL) MRI, to establish a biomarker useful in autism diagnosis.
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Diagnosis
Last updated Aug 23, 2026 00:00 UTC
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Glue instead of stitches: new fix for prolapse surgery?
Disease control CompletedLaparoscopic sacrocolpopexy is the consensual attitude of choice in genital prolapse but incurs problems of tolerance of implanted material. As an alternative to stapling and suturing, which cause vaginal erosion, we present a fixation technique using a sterile synthetic liquid t…
Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Brain scans and genes may reveal why some smokers Can't quit
Knowledge-focused CompletedBackground: \- Smoking is a difficult habit to quit, and some people find it more difficult to quit than others do. Nicotine is the substance in cigarettes that makes smoking so addictive. Nicotine changes some patterns of brain activity, and smokers have differences in brain ac…
Sponsor: National Institute on Drug Abuse (NIDA) • Aim: Knowledge-focused
Last updated Aug 29, 2026 00:00 UTC
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New sperm sorting technique could let parents pick Baby's sex
Disease control Recruiting nowThis study aims to demonstrate a reliable method of selecting gender specific sperm. X-bearing spermatozoa and Y-bearing spermatozoa will be identified from the density gradient layers. The selected gender specimen will then be utilized for assisted reproductive fertilization- in…
Sponsor: Weill Medical College of Cornell University • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New ADHD drug shows promise in small trial
Symptom relief CompletedThis was a Phase 2 exploratory study to evaluate the efficacy and safety of EB-1020 SR (centanafadine sustained release \[CTN SR\]) in treating participants who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) diagnostic criteri…
Phase 2 • Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC