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Bone drug injection may help dental anchors last longer

NCT ID NCT07546058

Disease control Sponsor: Latakia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether injecting a small amount of zoledronic acid near orthodontic miniscrews helps them stay in place. Sixty-eight patients each received the drug on one side of the mouth and a placebo on the other. The goal was to see if the drug reduces screw loosening and inflammation over six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
zoledronic acid (a bisphosphonate drug)
What this could lead to
If it works, this could offer a simple way to prevent orthodontic miniscrews from loosening, improving treatment outcomes.
What could go wrong
This is a small, completed trial with 68 patients. The drug's local use is experimental, and long-term safety or effectiveness in broader populations is unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

68 people

The number who actually took part.

Started

Dec 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

17 to 28 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Mild to moderate skeletal Class II Division 1 malocclusion with full-cusp Class II molar relationship, ANB angle between 4° and 6°, normal maxilla-mandibular plane angle (25° ± 5°), and indication for first premolar extraction to reduce overjet. Exclusion Criteria: * Periodontal disease or alveolar bone loss. * Craniofacial deformities. * Cleft lip or palate. * Impacted or missing teeth in the treatment area. * Systemic diseases or current medication affecting bone metabolism. * Poor gingival health. * Smoking or inadequate oral hygiene.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Orthodontic appliance complication

Contacts and locations

Locations

  • Latakia University

    Latakia, Latakia Governorate, Syria

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