Bone drug injection may help dental anchors last longer
NCT ID NCT07546058
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether injecting a small amount of zoledronic acid near orthodontic miniscrews helps them stay in place. Sixty-eight patients each received the drug on one side of the mouth and a placebo on the other. The goal was to see if the drug reduces screw loosening and inflammation over six months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
zoledronic acid (a bisphosphonate drug)
What this could lead to
If it works, this could offer a simple way to prevent orthodontic miniscrews from loosening, improving treatment outcomes.
What could go wrong
This is a small, completed trial with 68 patients. The drug's local use is experimental, and long-term safety or effectiveness in broader populations is unknown.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Latakia University
Latakia, Latakia Governorate, Syria