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Can two antibiotics beat one for Drug-Resistant typhoid?

NCT ID NCT07641348

Disease control Sponsor: Iqra Asghar Ali Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares giving one antibiotic (meropenem) versus two antibiotics (meropenem plus azithromycin) to children aged 2–16 with extensively drug-resistant (XDR) typhoid fever. The goal is to see which approach shortens fever faster. 94 children will be randomly assigned to either treatment, and researchers will track how quickly their fever goes away and stays away for over 48 hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
meropenem and azithromycin
What this could lead to
If it works, this could show that combining two antibiotics clears XDR typhoid fever faster than one alone, helping doctors choose the best treatment.
What could go wrong
This is a small, early-stage trial with only 94 children, so results may not apply broadly. The combination may also cause more side effects or not work better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 94 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 16 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* Inclusion Criteria 1. Children aged 2-16 years 2. Culture-confirmed XDR typhoid fever (resistant to first-line agents, fluoroquinolones, and third-generation cephalosporins) 3. Admitted to Children's Hospital \& Institute of Child Health, Lahore Informed consent obtained from parent/guardian Exclusion Criteria 1. Age \<2 years or \>16 years 2. Known allergy or contraindication to meropenem or azithromycin 3. Presence of severe comorbidities (e.g., congenital heart disease, chronic renal failure, immunodeficiency) 4. Patients already receiving carbapenem or azithromycin therapy prior to enrollment

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Conditions

The condition(s) this trial relates to.

typhoid fever

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Typhoid fever

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Child Health Scienes Lahore

    Lahore, Punjab Province, 52000, Pakistan

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