Can two antibiotics beat one for Drug-Resistant typhoid?
NCT ID NCT07641348
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares giving one antibiotic (meropenem) versus two antibiotics (meropenem plus azithromycin) to children aged 2–16 with extensively drug-resistant (XDR) typhoid fever. The goal is to see which approach shortens fever faster. 94 children will be randomly assigned to either treatment, and researchers will track how quickly their fever goes away and stays away for over 48 hours.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
meropenem and azithromycin
What this could lead to
If it works, this could show that combining two antibiotics clears XDR typhoid fever faster than one alone, helping doctors choose the best treatment.
What could go wrong
This is a small, early-stage trial with only 94 children, so results may not apply broadly. The combination may also cause more side effects or not work better.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Child Health Scienes Lahore
Lahore, Punjab Province, 52000, Pakistan
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••