Can two antibiotics beat one for Drug-Resistant typhoid?
NCT ID NCT07641348
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares giving one antibiotic (meropenem) versus two antibiotics (meropenem plus azithromycin) to children aged 2–16 with extensively drug-resistant (XDR) typhoid fever. The goal is to see which approach shortens fever faster. 94 children will be randomly assigned to either treatment, and researchers will track how quickly their fever goes away and stays away for over 48 hours.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- meropenem and azithromycin
- What this could lead to
- If it works, this could show that combining two antibiotics clears XDR typhoid fever faster than one alone, helping doctors choose the best treatment.
- What could go wrong
- This is a small, early-stage trial with only 94 children, so results may not apply broadly. The combination may also cause more side effects or not work better.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Child Health Scienes Lahore
Lahore, Punjab Province, 52000, Pakistan
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