Oral vaccine study probes gut barrier changes in healthy volunteers
NCT ID NCT04083950
First seen Dec 22, 2025 · Last updated Jun 23, 2026 · Updated 23 times
Summary
This study looks at whether taking an oral typhoid vaccine temporarily makes the gut more 'leaky' and how the immune system responds. Ten healthy adults will receive the vaccine and a low-dose aspirin challenge. Researchers will measure sugar levels in urine and immune cells in blood to track changes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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USDA, ARS, Western Human Nutrition Research Center
Davis, California, 95616, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ty21a typhoid oral vaccine (Vivotif) and aspirin
What this could lead to
If successful, this could help researchers understand how oral vaccines affect the gut barrier, potentially improving vaccine design.
What could go wrong
This is a very small, early-phase study with only 10 participants, so results may not apply broadly. The vaccine is known to be safe but may cause mild digestive upset.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.