Could a common steroid improve dental bone graft healing?
NCT ID NCT06556095
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
After a tooth is removed, a bone graft is often placed to prevent the bone from shrinking. This study tested whether hydrating the bone graft with dexamethasone (a steroid) instead of saline improves healing. 44 adults who needed a tooth extraction and planned dental implant took part. Researchers measured new bone formation and ridge changes 16 weeks later.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Dexamethasone
- What this could lead to
- If successful, this could point toward a simple way to improve bone graft healing after tooth extraction.
- What could go wrong
- This is a very early, small study (44 people) that only looked at healing under a microscope. Results may not apply to everyone or change standard practice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
-
44 people
The number who actually took part.
- Started
-
Sep 2024
- Finished
-
Jan 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 89 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female patient aged 18 to 89 * One tooth, excluding molars, that has been identified by dental faculty as requiring a single tooth extraction * A dental implant is indicated and treatment planned to replace the missing tooth * Site has adequate restorative space for a dental implant-retained restoration * Site has at least 10mm of alveolar bone height, without impinging on the maxillary sinus or inferior alveolar canal. * Site has a dehiscence of the buccal or lingual bony plate of the tooth socket extending no more than 50% of the total depth of the socket. * Female patients who have undergone a hysterectomy, tubal ligation, or menopause, and non-pregnant women of child-bearing potential. * Patients are nonsmokers or former smokers. Current smokers may be included if they smoke \<10 cigarettes per day Exclusion Criteria: * Patient allergic to dexamethasone * Will not cooperate with the follow-up schedule. * Patients will not be entered who are mentally incompetent, prisoners, or pregnant. * Pregnant women or women intending to become pregnant during the study period (as confirmed verbally; an over-the-counter pregnancy test will be provided if pregnancy status is unknown or suspected). Patients who become pregnant during the study will be withdrawn and standard care will be delivered. * Smokers who smoke \>10 cigarettes per day * Clinical and/or radiographic determinations which will preclude inclusion in this study are: Active infection other than periodontitis; Inadequate bone dimensions or restorative space for a dental implant; Presence of a disease entity, condition or therapeutic regimen which decreases probability of soft tissue and bony healing, e.g., poorly controlled diabetes, chemotherapeutic and immunosuppressive agents, autoimmune diseases, history of bisphosphonate use or long-term steroid therapy.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
UT Health Science Center at San Antonio, School of Dentistry
San Antonio, Texas, 78229, United States
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Other studies related to the condition(s) this trial covers.
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