Could a Nicotine-Free cigarette break the habit?
NCT ID NCT07755891
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial tests whether switching to cigarettes with very low nicotine content can reduce how much people smoke and their nicotine exposure. Adult daily smokers in South Korea will be randomly assigned to either very low nicotine or normal nicotine cigarettes for 12 weeks. Researchers will track smoking behavior, nicotine levels, cravings, and withdrawal symptoms to see if the low-nicotine option helps people smoke less.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Very low nicotine content (VLNC) cigarettes
- What this could lead to
- If effective, very low nicotine cigarettes could help smokers cut down or quit, reducing nicotine dependence and related health risks.
- What could go wrong
- The trial is early and may not show lasting changes in smoking behavior. Participants might compensate by smoking more or using other nicotine products.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 300 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Jan 2027
An estimate. Start dates often move.
- Expected to finish
-
Jun 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
19 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 19 years or older. * Current daily smoker of at least 10 conventional cigarettes per day for the past 12 months. Concurrent heated tobacco product use is permitted only when the participant meets the conventional-cigarette criterion and is a conventional-cigarette-dominant user. * No intention to quit smoking within the next month. * Willingness to switch entirely to the assigned study cigarettes during the trial period. * Ability to understand written Korean and complete study procedures independently. * Ability to use a smartphone for EMA data collection. * Ability to provide written informed consent. Exclusion Criteria: * Current regular use of electronic cigarettes (e-cigarettes). * Self-reported pregnancy, planning pregnancy during the study period, or breastfeeding; or positive pregnancy test at screening for participants who can become pregnant. * Current use of pharmacological smoking cessation aids, including varenicline, bupropion, or nicotine replacement therapy. * Serious psychiatric disorder that would interfere with study participation, such as psychosis or severe depression. * Any medical condition that contraindicates continued smoking, including prespecified safety thresholds such as systolic blood pressure of 160 mmHg or higher, heart rate of 105 beats/min or higher, or heart rate below 45 beats/min with symptoms. * Any other factor that may affect adherence or pose a health risk to the participant. * Inability to read and write sufficiently to complete study activities. * No reliable way for the research team to communicate with the participant by telephone or email. * Current participation in another tobacco- or nicotine-related research study. * Prior participation in a similar tobacco or nicotine intervention trial involving SPECTRUM research cigarettes or manipulation of cigarette nicotine content, if determined to affect eligibility.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Cigarette smoking are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Medical Education Building, Seoul National University College of Medicine
Seoul, 03080, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Nicotine flux: a new way to gauge how addictive E-Cigarettes are?
- Practice quitting: a new way to help smokers who Aren't ready to stop?
- Can a combined program help veterans in substance use care quit smoking?
- Can a Quit-Smoking program built for transgender adults help them stop?
- Mindfulness meets wearable tech in a new bid to break the smoking habit
- Could a pyramid-shaped workout help smokers breathe easier?