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New amputation technique may restore natural limb movement for amputees

NCT ID NCT06371209

Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study looks at a new type of amputation called the Ewing amputation, which connects muscles in the residual limb to allow more natural feedback when using a prosthetic. Researchers will measure muscle activity and movement patterns in people who have had this procedure and compare them to their healthy leg and to standard amputees. The goal is to see if the Ewing amputation helps the brain interpret prosthetic movement more like a real joint.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Modified amputation procedure (Ewing amputation)
What this could lead to
If successful, this could validate a surgical approach that helps amputees feel more natural joint movement and control with their prosthetic limb.
What could go wrong
This is a small observational study, not a treatment trial. It measures movement patterns, not long-term outcomes, and results may not apply to all amputees.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 32 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Trans-tibial amputees local to or visiting the Massachusetts area

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Unilateral lower extremity amputees * Greater than 12 months post-amputation procedure * Possession and use of a working prosthesis as determined by subject's ability to wear it for 8 hours daily * A stable, well-fitting socket as indicated by no prosthetic modifications within the prior 14 days and no plans to modify it within the following 30 days * Follow-up visit with their prosthetist within the past 3 months * The ability to walk independently without an assistive device * The ability to follow directions and communicate pain or discomfort Exclusion Criteria: * Patients beyond the stated age restrictions will be excluded * Patients who have any underlying neurologic, orthopedic, or cardiopulmonary impairment that affects their gait as assessed by the study clinician. * Patients with any medical or functional limitations preventing them from ambulating safely and independently without an assistive device. * Patients will be excluded who do not have a prosthesis

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Agonist-antagonist myoneural interface Lower extremity amputation Trans-tibial amputation Traumatic lower extremity amputation

Contacts and locations

Locations

  • Mass General Brigham

    Boston, Massachusetts, 02129, United States

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