Can vaginal estradiol or moisturizer ease menopause symptoms in women with HIV?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * female * at least 40 years old * menopausal (no menses in 12 months) within 2 years of last menstrual period or perimenopausal in the late menopausal transition, defined as an interval of amenorrhea greater than or equal to 60 days * have symptoms of the genitourinary syndrome of menopause (GSM) which developed within the prior 2 years. Symptoms of GSM include vaginal symptoms including dryness, soreness, itching, irritation and dyspareunia and/or urinary symptoms including urgency, frequency and recurrent urinary tract infections (UTIs) Exclusion Criteria: * Unexplained or unevaluated abnormal genital bleeding * Current or suspected pregnancy * Desired pregnancy * If less than 55 years old, have had a hysterectomy and have at least one ovary (as menopause cannot be determined in this case by amenorrhea alone) * Pelvic or vaginal surgery in the prior 60 days * Used systemic reproductive hormones in the last 2 months * Used antibiotics in the last 30 days * Used immunosuppressive medications in the prior 60 days including biologics, chemotherapeutics or post transplant immunosuppressive medications * Used any vaginal or vulvar preparations in the last month * Current active vaginal infection diagnosed at study entry * Any serious disease or condition that may interfere with study compliance * Current or previous history of breast cancer or estrogen dependent cancer (e.g., ovarian, endometrial) * Current or previous history of deep vein thrombosis or pulmonary embolism * Current or previous history of myocardial infarction or stroke * Known clotting disorder including Protein C, Protein S and antithrombin deficiency, Factor V Leiden or prothrombin mutations * Known severe liver disease including cirrhosis or active Hepatitis B * Known allergic reaction to Vagifem (estradiol vaginal tablet) or Replens