Why some ICU patients Can't leave the ventilator: diaphragm weakness under the microscope
NCT ID NCT03140267
First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This study followed 22 ICU patients who had trouble being taken off a breathing machine (ventilator). Researchers measured two key aspects of the diaphragm—strength and endurance—over 18 hours to see which one is more lacking. The goal was to understand the root cause of weaning failure so that future breathing muscle training can be more effective.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help design better breathing muscle training programs for ICU patients struggling to come off ventilators.
- What could go wrong
- This is a very small, observational study (22 people) that only measures muscle function—it does not test any treatment, so it may not lead to direct improvements.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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22 people
The number who actually took part.
- Started
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May 2017
- Finished
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Jan 2020
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient ventilated more than 18h in a controlled mode; * First single breathe trial of 2 hours failure; * Presence of sevrability criterias definied by the European consensus conference in 2007 as usually used: * diminution of the sedfative agents ; * Patients with spontaneous beath in VAC mode or patient ventilated in a VSAI-PEP mode; * PaO2/FiO2 ≥150; * Absence d'inotropes ou de vasopresseurs à forte dose ou dose croissante (\<1mg/h); * SaO2 \> 90% with FiO2 ≤ 50%; * PEP ≤ 8cmH2O; * Corporal température between 36°C and 39°C; * Glasgow Score ≥ 8; * Patient or family consent. Exclusion Criteria: * Age \< 18 years ; * medically unstable; * Poor vital pronostic at very short term; * Cardiac arrest with a poor neurological prognostic; * Neuromuscular disease ; * Tracheostomy ; * Current pregnancy ; * Patients with guardianship or trusteeship.
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Haut-Lévêque
Bordeaux, 33000, France
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Hôpital Pellegrin
Bordeaux, 33000, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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