Swallow a sponge to check for esophageal cancer?
NCT ID NCT07490340
First seen Mar 27, 2026 · Last updated Jun 19, 2026 · Updated 15 times
Summary
This study tests a device called Endosign, which is a sponge on a string that patients swallow to collect cells from the esophagus. The goal is to see if this simple, non-sedation method can provide good enough samples to replace regular endoscopies for monitoring Barrett's esophagus, a condition that can lead to esophageal cancer. The trial involves 60 adults with Barrett's esophagus, both with and without early cancer changes. If it works, it could make surveillance much easier and cheaper.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Amsterdam University Medical Centre, loc. VUmc
Amsterdam, North Holland, 1081HV, Netherlands
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Endosign (sponge-on-a-string sampling device)
What this could lead to
If successful, this could offer a less invasive, cheaper way to monitor Barrett's esophagus, potentially catching esophageal cancer earlier.
What could go wrong
This is a small pilot study (60 people) testing only sample quality, not long-term outcomes. The device may not reliably replace endoscopy, and results may not apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.