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Can this toothpaste fix cavities before they start?

NCT ID NCT07419763

Disease control Sponsor: Church & Dwight Company, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a special toothpaste could help repair early tooth decay. Thirty adults wore a dental device with enamel samples for one week while using different toothpastes. Researchers measured how much the enamel hardened and how much fluoride it absorbed. The goal was to see if the test toothpaste worked better than a regular fluoride toothpaste or a fluoride-free one.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fluoride toothpaste with potassium nitrate and sodium bicarbonate
What this could lead to
If it works, this toothpaste could help reverse early tooth decay and strengthen enamel, reducing the need for fillings.
What could go wrong
This is a small, early-stage study with only 30 people, and it measured lab effects on enamel, not actual cavity prevention. Results may not apply to real-world use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Apr 2025

Finished

Jun 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ≥18 years * Good general and oral health * Normal unstimulated saliva flow (≥1.5 mL unstimulated saliva in 5 minutes) * ≥16 teeth and functional maxillary dentition to support palatal appliance * Agree to abstain from other oral care products and preventive dental procedures during study * No advanced periodontal disease, no visible untreated caries * If female, not pregnant or breastfeeding (self-reported) * No significant oral soft tissue pathology; no peri/oral piercings; no removable partial dentures * No antibiotics or immunosuppressives within 30 days of screening * No palatal torus; no medical condition that would interfere with safety * No allergy or significant adverse events to impression materials, acrylics, or common oral product Exclusion Criteria: * Unable to tolerate appliance or comply with procedures * Oral pathology that interferes with participation * Use of fluoride toothpaste during washout periods * Participation in another appliance study within the last 4 week

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Conditions

The condition(s) this trial relates to.

dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental caries

Contacts and locations

Locations

  • Therametric Technologies, Inc.

    Noblesville, Indiana, 46060, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.