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Could a cholesterol drug save infected baby teeth?

NCT ID NCT07264842

Disease control Sponsor: Dow University of Health Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two treatments for infected baby molars in children aged 5 to 8. One group gets a standard antibiotic paste, the other gets simvastatin (a common cholesterol drug). Both are placed inside the tooth after cleaning, and the tooth is sealed. Researchers will check for pain, swelling, and healing on X-rays after 1, 2, and 3 months. The goal is to see if simvastatin can be a good alternative to antibiotics.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Simvastatin paste or Triple Antibiotic Paste (Ciprofloxacin + Metronidazole + Cefixime)
What this could lead to
If simvastatin works, it could offer a simpler, antibiotic-free way to treat infected baby teeth and preserve them until they fall out naturally.
What could go wrong
This is a small, early-phase study with only 60 children and short follow-up (3 months). Simvastatin may not work as well as the standard antibiotic paste, and results may not apply to all children.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

5 to 8 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Young, healthy patient, ranging in age from 5-8 years. * Has parents/ guardians who give consent to allow their minor to participate in the study and willing to monitor their progress. * Having maxillary and mandibular primary molars with: * Spontaneous pain or tenderness to percussion. * Deep cavity extending to the pulp chamber. * Chronic Abscess or draining sinus. * Restorable. * To be kept for less than a year. * Irregular mobility that is not related to exfoliation. Exclusion Criteria: * Uncooperative patients. * Children with a history of allergic reaction with antibiotics. * Teeth with physiological root resorption but root length is more than two thirds, root canal obliteration, severe internal resorption, internal calcifications, or piercing into the bifurcation.

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulpal necrosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dow International Dental College, Chanesar goth.

    RECRUITING

    Karachi, Sindh, 75950, Pakistan

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