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Could a tooth-based gel save kids' teeth? new trial explores regenerative dental treatment

NCT ID NCT07210359

Disease control Sponsor: Kafrelsheikh University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether two forms of demineralized dentin matrix (a material made from tooth tissue) can help regenerate immature permanent teeth in children aged 9 to 15. The trial compares these materials to a standard sealing material called RetroMTA. Over 12 months, researchers will check if the treatments improve root growth and healing. The goal is to find a better way to treat damaged teeth and avoid tooth loss.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
demineralized dentin matrix (DDM) and RetroMTA
What this could lead to
If successful, this could offer a better way to help damaged immature teeth grow stronger roots and heal, potentially saving teeth that might otherwise be lost.
What could go wrong
This is a small, early-stage trial with only 36 participants, so results may not apply to everyone. The materials are still experimental, and long-term success is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

9 to 15 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy patients (i.e., free of any systemic diseases). * Patients presenting with immature permanent single-rooted teeth. * Age: 9 -15 years. * Teeth diagnosed as either vital (asymptomatic irreversible pulpitis or symptomatic irreversible pulpitis and the bleeding didn't stop after 5 minutes application of hemostatic agent) or non-vital pulp. Exclusion Criteria: * Patients who are allergic to any drugs used in this study or with systemic illness * Teeth that are grossly decayed or fractured and require post and core as final restorations * Presence of periodontal pockets greater than 4 mm. * Radiographical evidence of apical foramen less than 1 mm. * Presence of periapical radiolucency exceeding 10 mm. * Presence of external or internal root resorption. * Patients with a history of major surgeries like cardiac, kidney transplantation, haemodialysis.

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulpal necrosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • KafrelsheikhU

    RECRUITING

    Kafr ash Shaykh, Kafr Elsheikh, 33511, Egypt

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