Could a tooth-derived gel save kids' teeth from extraction?
NCT ID NCT07210359
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 31 times
Summary
This study tests whether two forms of demineralized dentin matrix (a material made from tooth tissue) can help regenerate roots in immature permanent teeth with dead nerves. Thirty-six children aged 9 to 15 will receive one of three treatments: a dentin matrix hydrogel, a dentin matrix combined with a light-cured liner, or a standard material called RetroMTA. The goal is to see which material best promotes root growth and healing over 12 months.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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KafrelsheikhU
RECRUITINGKafr ash Shaykh, Kafr Elsheikh, 33511, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
demineralized dentin matrix (DDM) and RetroMTA
What this could lead to
If successful, this could provide a better way to help damaged immature teeth grow stronger roots and avoid extraction.
What could go wrong
This is a small, early-stage trial with only 36 participants, so results may not apply to everyone. The materials are new and their long-term safety and effectiveness are not yet proven.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.