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Wisdom tooth recovery: could these enzyme pills beat standard care?

NCT ID NCT07304882

Symptom relief Sponsor: University of Science and Technology, Yemen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding serratiopeptidase or escin to standard painkillers and antibiotics helps people recover better after having a lower wisdom tooth removed. Twenty-four healthy adults were randomly assigned to one of three groups. Researchers measured facial swelling, jaw stiffness, and pain levels over time to see which combination worked best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
serratiopeptidase and escin (as add-ons to standard antibiotics and painkillers)
What this could lead to
If one of these works better, it could give dentists a new option to help patients recover faster after wisdom tooth surgery.
What could go wrong
This is a very small study (24 people) and only looks at short-term recovery after one type of surgery. Results may not apply to other procedures or larger groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

24 people

The number who actually took part.

Started

Nov 2023

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Medically healthy. * Presence of two mandibular third molars indicated for surgical extraction. * No history of pericoronitis or other signs of inflammation within the past 30 days. Exclusion Criteria: * Current use of other medications such as NSAIDs or corticosteroids. * Known allergy to any drugs administered in this study. * Pregnancy or breastfeeding. * History of diabetes or hypertension. * Previous irradiation to the maxillofacial region. * Intellectual disability or inability to attend follow-up visits. * Presence of acute or subacute pericoronitis.

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Conditions

The condition(s) this trial relates to.

Pain Trismus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impacted mandibular third molar extraction Post operative complications

Contacts and locations

Locations

  • University of Science and Technology

    Sanaa, Sana'a, Yemen

More trials for these conditions

Other studies related to the condition(s) this trial covers.