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Cleaner toilets, stronger vaccine? study tests Sanitation's role

NCT ID NCT03313128

Knowledge-focused Sponsor: London School of Hygiene and Tropical Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether having better sanitation helps the oral rotavirus vaccine work better in babies. Researchers followed 261 infants in low-income areas of Maputo, Mozambique, comparing those with improved sanitation to those without. They measured immune response and checked for gut infections and inflammation that might interfere with the vaccine.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could show that improving sanitation helps rotavirus vaccines work better in low-income settings.
What could go wrong
This is an observational study, not a treatment trial. Results may not prove cause and effect, and findings may not apply to other regions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

261 people

The number who actually took part.

Started

Oct 2017

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pregnant women of gestational age between 3-9 months (and postpartum) residing in the historic intervention and control compounds of a previous sanitation trial (NCT02362932) and their descendant(s) \[infant(s)\] of that pregnancy.

Ages

16 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Mother residing in an intervention or control compound of a previous sanitation trial (NCT02362932) for at least 6 months prior to recruitment and not intending to switch study compound over the next 9 months 2. Mother being pregnant and having gestational age between 3 and 9 months or being puerperal (up to 40 days postpartum) 3. Mother planning to use the prenatal care, delivery and vaccination services provided by the Ministry of Health of Mozambique 4. Mother able to understand and complete the informed consent process and allow your newborn to participate in the study 5. Mother at least 16 years of age 6. Infant eligible to receive rotavirus vaccination Exclusion criteria: 1. Infant whose medical team considers that they cannot be part of the study 2. Infant with complications associated with gestation, childbirth or postpartum, including congenital malformations 3. Infant with any medical, psychiatric or social condition, occupational reason, or other responsibility on the part of the pregnant woman, which, in the opinion of the investigator, is a contraindication to protocol compliance or impedes the participant's ability to give informed consent 4. Infant who has already received the rotavirus vaccine

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Conditions

The condition(s) this trial relates to.

intestinal infectious disease Rotavirus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Enteric infections Environmental enteric dysfunction Rotavirus infections

Contacts and locations

Locations

  • Centro de Investigação em Saúde da Polana Caniço (CISPOC)

    Maputo, 264, Mozambique

More trials for these conditions

Other studies related to the condition(s) this trial covers.