Which IV fluid is safer for heat stroke? study investigates
NCT ID NCT05921695
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether using Ringer's lactate instead of normal saline during emergency treatment for heat stroke could reduce the risk of acute kidney injury. Researchers planned to enroll 104 adults diagnosed with heat stroke, giving one group standard saline and the other group Ringer's lactate. The goal was to see if limiting high-chlorine fluids like saline lowers kidney damage and death rates. The trial was terminated early, so results are limited.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- normal saline and Ringer's lactate
- What this could lead to
- If this study yields clear results, it could help emergency doctors choose the best fluid to prevent kidney damage in heat stroke patients.
- What could go wrong
- The trial was terminated early, so results may be incomplete. It is a small, single-center study, so findings may not apply broadly.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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104 people
The number who actually took part.
- Started
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May 2023
- Finished
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Jun 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * ≥ 18 years * diagnosed as heat stroke * Informed consent from patients or family members. Exclusion Criteria: * need immediate cardiopulmonary resuscitation * transferred from another hospital * with original end-stage renal disease or dialysis * with severe organ damage * pregnant women
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dongyang People's Hospital
Dongyang, China
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Jinhua Municipal Central Hospital
Jinhua, China
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Jinhua People's Hospital
Jinhua, China
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Lanxi People's Hospital
Lanxi, China
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The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, 310000, China
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Yiwu Central Hospital
Yiwu, Zhejiang, China
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YongKang First People's Hospital
Guli, Zhejiang, 321300, China
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