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Hidden heat risk: one copy of CF gene may raise danger

NCT ID NCT06847256

Knowledge-focused Sponsor: University of Iowa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether people who carry one copy of the cystic fibrosis gene (but don't have the disease) are more likely to get dehydrated or have heat-related problems. Researchers will compare 100 carriers with 100 non-carriers using surveys and a 45-minute sauna challenge. The goal is to understand if this genetic trait affects how the body handles heat.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help identify people who are more prone to heat-related illness, leading to better prevention advice.
What could go wrong
This is an early observational study with only 200 participants. It does not test a treatment, so results may not lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals who have previously been genotyped as CF Carriers or Controls.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Previously genotyped as a CF carrier or control * Comfortable speaking/reading English Exclusion Criteria: * Previously genotyped as a CF patient * Diagnosis of Type 1 or Type 2 diabetes * History of heart attack, stroke, heart failure, or atherosclerosis * Currently pregnant * Currently taking beta blockers or diuretics * Prisoner status * Unable to provide own written informed consent

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Conditions

The condition(s) this trial relates to.

Dehydration exercise-induced malignant hyperthermia Heat Stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carrier state Dehydration Heat stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Iowa Health Care

    RECRUITING

    Iowa City, Iowa, 52242, United States

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