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Root canal pain showdown: which sealer hurts less?

NCT ID NCT04885686

Symptom relief Sponsor: Septodont Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two root canal sealers, Endomethasone N (with hydrocortisone) and Endomethasone SP (without), to see which one reduces pain better after a root canal. 300 adults needing root canal treatment were randomly assigned to one sealer and recorded their pain for 7 days. The goal was to find out if the hydrocortisone-containing sealer leads to less discomfort.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Endomethasone N and Endomethasone SP root canal sealers
What this could lead to
If Endomethasone N works better, dentists may have a new option to reduce pain after root canals.
What could go wrong
This is a completed study, but results are not yet published. The difference between sealers may be small or not meaningful for patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

300 people

The number who actually took part.

Started

Jun 2021

Finished

Jun 2022

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult male or female (age ≥ 18 years); * Patient requiring root canal treatment or retreatment; * Patient who will need a single visit for the root canal therapy, for a mature molar or second premolar, with or without pre-operative pain * Patient who received information and gave written consent (signed informed consent form); * Subject affiliated to a health insurance system, or is a beneficiary (art. L.1121-11, Code of Public Health, France). Exclusion Criteria: * Pulpotomy or pulpectomy performed at a prior visit; * Tooth with apical calcification (sealer unable to reach the root apex); * Tooth with suspected root perforation; * Immature tooth (too wide root apex requiring an apexification); * Other dental treatment ongoing or scheduled within the study period; * At least one symptomatic tooth among those that are not included in this study * Known hypersensitivity to steroids, local anesthetics, or any component of study medical devices; * Subject using long term anti-inflammatory drugs; * Use of illicit substances during the 48h before the first visit (cannabis, cocaine…); * Presence of any significant medical finding or significant history such as uncontrolled systemic diseases that may impact the safety, the interpretation of the results and/or the participation of the subject in the study according to the opinion of the investigator; * Subject who cannot be contacted in case of emergency (phone number); * Simultaneous participation in another clinical trial or subject still within the exclusion period of a previous clinical trial; * Vulnerable subjects (art. L.1121-5 and L.1122-1-2, Code of Public Health, France; art. 66 of the Regulation (EU) 2017/745 on medical devices)

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Root canal obturation

Contacts and locations

Locations

  • Cabinet Dentaire

    Cherbourg, 50100, France

  • Cabinet dentaire

    Agon-Coutainville, 50230, France

  • Cabinet dentaire

    Betton, 35830, France

  • Cabinet dentaire

    Chartres-de-Bretagne, 35131, France

  • Cabinet dentaire

    Cherbourg, 50110, France

  • Cabinet dentaire

    Dinan, 35800, France

  • Cabinet dentaire

    Équeurdreville-Hainneville, 50120, France

  • Cabinet dentaire

    Lamballe, 22400, France

  • Cabinet dentaire

    Pluguffan, 29700, France

  • Cabinet dentaire

    Quimper, 29000, France

  • Cabinet dentaire

    Rennes, 35000, France

  • Cabinet dentaire

    Saint-Aubin-de-Médoc, 33160, France

  • Cabinet dentaire

    Tinténiac, 35190, France

  • Centre de santé dentaire Chevaleret

    Paris, 75013, France

  • Centre dentaire Flandre

    Paris, 75019, France

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