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New strategy aims to cut unnecessary antibiotics in pneumonia care

NCT ID NCT05568654

Disease control Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study tests two approaches to reduce the overuse of broad-spectrum antibiotics in adults hospitalized with community-acquired pneumonia. Researchers will compare rapid diagnostic testing and pharmacist-led de-escalation, alone or together, against usual care. The goal is to give the right antibiotics only when needed, lowering side effects and drug resistance. About 12,500 patients across multiple hospitals will take part.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

28,580 people

The number who actually took part.

Started

Nov 2022

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for patient's records: 1. Men or women greater than or equal to 18 years of age 2. Admitted to a participating (i.e. enrolled and randomized) hospital 3. Admitting diagnosis of pneumonia Exclusion Criteria: 1. Admission to intensive care unit within 24 hours of hospital admission 2. Comfort care measures only 3. Cystic fibrosis 4. Discharged from an acute care hospital in the past week 5. Patients not eligible for empiric therapy due to a known pathogen (any positive blood or respiratory cultures in the 72 hours prior to admission)

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Conditions

The condition(s) this trial relates to.

Community-Acquired Pneumonia pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Antimicrobial stewardship Community-acquired pneumonia Point of care testing

Contacts and locations

Locations

  • Akron General Hospital

    Akron, Ohio, 44307, United States

  • Avon Hospital

    Avon, Ohio, 44011, United States

  • Cleveland Clinic Main Campus

    Cleveland, Ohio, 44195, United States

  • Euclid Hospital

    Euclid, Ohio, 44119, United States

  • Fairview Hospital

    Fairview Park, Ohio, 44111, United States

  • Hillcrest Hospital

    Mayfield Heights, Ohio, 44124, United States

  • Indian River Hospital

    Vero Beach, Florida, 32960, United States

  • Lutheran Hospital

    Cleveland, Ohio, 44113, United States

  • Marymount Hospital

    Garfield Heights, Ohio, 44125, United States

  • Medina Hospital

    Medina, Ohio, 44256, United States

  • South Pointe Hospital

    Warrensville Heights, Ohio, 44122, United States

  • Weston Hospital/Cleveland Clinic Florida

    Weston, Florida, 33331, United States

More trials for these conditions

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