Can a Plant-Based diet slow kidney disease? singapore study seeks answers
NCT ID NCT07544524
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether a diet rich in plant-based foods is feasible and safe for people with stage 3 or 4 chronic kidney disease (CKD) in Singapore. Forty adults will either follow a plant-based diet or a standard kidney-friendly diet, with regular dietitian support. The main goal is to see if people can stick to the diet and find it acceptable, while also checking for risks like high potassium and potential benefits like slower disease progression.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- predominantly plant-based diet
- What this could lead to
- If successful, this could show that a plant-based diet is a practical way to help manage chronic kidney disease and slow its progression in Asian populations.
- What could go wrong
- This is a small, early feasibility study with only 40 participants, so results may not apply broadly. There is also a risk of high potassium levels (hyperkalaemia) or nutritional deficiencies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 79 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age 21-79 (Only adults who can give consent will be recruited. Older adults aged 80 are not included to reduce the risk of confounding due to age-related frailty, sarcopenia and multimorbidity. Additionally, older adults may have different nutritional needs and energy requirements) 2. CKD stage 3-4 (baseline eGFR 15-60ml/min/1.72m2 for the past 6 months) 3. Willingness to see a dietitian and follow either a standard CKD diet or a predominantly plant-based CKD diet 4. On maximum tolerated dose of ACE-inhibitors (Angiotensin converting enzyme inhibitors) or ARB (Aldosterone receptor blocker) as determined by Renal Physician in charge 5. Able to provide informed consent Exclusion Criteria: * Transplant patients (who will tend to have more variable trajectories, immunosuppression related challenges etc which may make this study less feasible) * Pregnant or lactating patients (who have different nutritional requirements than the standard CKD patients) * Patients who were on any special diet for at least 1 month prior to recruitment (inclusive of * long-term vegans or vegetarians) - excluded because they already have stable dietary habits * Age \<21 or \>/= 80 (Avoid growing children who have different nutritional requirements and advanced elderly who are more likely to have malnutrition or sarcopenia due to other pre-existing causes) * Those who have seen a dietitian for CKD previously * Patients with severe ischemic heart disease, decompensated liver cirrhosis, malabsorptive diseases or malignancy * Patients with BMI \<18.5 or \>40 * Patients with glomerulonephritis, genetic kidney disease or polycystic kidney disease * Baseline serum potassium 5.0 and above * Patients who are unable to modify their diet due to socio-economic issues. * Exclude patients with acute kidney injury (AKI) in the past 6 months prior to study (unstable renal disease
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Changi General Hospital
RECRUITINGSingapore, 529889, Singapore
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