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Blood clue may predict brain fog after surgery in seniors

NCT ID NCT07652008

Knowledge-focused Sponsor: Nanjing First Hospital, Nanjing Medical University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates whether a molecule called PK2 in the blood is linked to thinking and memory problems that some older adults experience after surgery. Researchers will measure PK2 levels in 40 patients aged 65 to 80 before and after hip replacement surgery, and compare those levels with cognitive test results. The goal is to better understand and potentially predict these post-surgery cognitive changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If PK2 levels are linked to cognitive problems after surgery, this could point toward a way to identify at-risk patients earlier.
What could go wrong
This is a small observational study with only 40 participants, so results may not apply to everyone. It looks at a connection, not a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of elderly patients aged 65 to 80 years with ASA physical status Class Ⅰ-Ⅲ who are undergoing hip replacement surgery. Patients are excluded if they have an MMSE score ≤ 24, severe cardiac, pulmonary, hepatic or renal dysfunction, recent use of sedatives/antidepressants or alcohol abuse, severe mental disorders (e.g., depression, schizophrenia, bipolar disorder, mental retardation), a history of severe craniocerebral injury, cerebrovascular disease, hydrocephalus, intracranial tumor or other neurological diseases (e.g., Parkinson's disease, Huntington's disease, epilepsy), severe visual or hearing impairment, or inability to complete cognitive function tests due to advanced age, low educational level or other factors.

Ages

65 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 65 years and ≤ 80 years * ASA physical status Class Ⅰ-Ⅲ * Elderly patients undergoing hip replacement surgery Exclusion Criteria: * Mini-Mental State Examination (MMSE) score ≤ 24 * Severe cardiac, pulmonary, hepatic or renal dysfunction * Recent use of sedatives or antidepressants, or alcohol abuse * Patients with severe mental disorders including depression, schizophrenia, bipolar disorder, mental retardation, etc. * History of severe craniocerebral injury, cerebrovascular disease, hydrocephalus, intracranial tumor, or other neurological diseases (e.g., Parkinson's disease, Huntington's disease, epilepsy) * Severe visual or hearing impairment * Inability to complete cognitive function tests due to advanced age, low educational level, or other factors

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Perioperative neurocognitive disorders

How to take part

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  1. The official record

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