New drug trial hopes to tame Hard-to-Treat cancers
NCT ID NCT05571839
First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 21 times
Summary
This early-stage study tests a new drug, PF-08046049/SGN-BB228, in people with advanced melanoma and other solid tumors that have spread or stopped responding to standard treatments. The main goal is to find a safe dose and understand side effects. About 41 participants will take part in three phases to determine the best dose and check if the drug works.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Ambulatory Care Center at NYU Langone Medical Center
New York, New York, 10016, United States
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BWH
Boston, Massachusetts, 02115, United States
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Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
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Clinical Research Center Dermatology (CRCD) Dermatoonkologie Charité - Universitätsmedizin Berlin
Berlin, 10115, Germany
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Clinical Research Center Dermatology (CRCD) Dermatoonkologie Charité - Universitätsmedizin Berlin
Berlin, 10117, Germany
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Dana-Farber Cancer Institute (DFCI)
Boston, Massachusetts, 02215, United States
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Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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Insitut Gustave Roussy
Villejuif, Cedex, 94805, France
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Institut Gustave Roussy
Villejuif, 94805, France
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Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
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Laboratory Corporation of America
Raritan, New Jersey, 08869, United States
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Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
New York, New York, 10016, United States
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NYU Langone Hospitals, NYU Langone Rusk Ambulatory Surgical Pharmacy
New York, New York, 10016, United States
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NYU Langone Medical Center(Tisch Hospital)
New York, New York, 10016, United States
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Northwestern Medical Group
Chicago, Illinois, 60611, United States
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Northwestern Memorial Hospital
Chicago, Illinois, 60611, United States
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Presbyterian/St. Lukes Medical Center
Denver, Colorado, 80218, United States
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Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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Quest Diagnostics Incorporated - Denver
Denver, Colorado, 80209, United States
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Ronald Reagan UCLA Medical Center, Drug Information Center
Los Angeles, California, 90095, United States
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Texas Oncology - Baylor Sammons Cancer Center
Dallas, Texas, 75251, United States
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Texas Oncology-Baylor Charles A. Sammons Cancer Center
Dallas, Texas, 75246, United States
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The Angeles Clinic and Research Institue, A Cedars-Sinai Affiliate
Los Angeles, California, 90025, United States
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The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate (Emergency Back-up only)
Santa Monica, California, 90404, United States
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The Beatson West of Scotland Cancer Centre
Glasgow, Glasglow CITY, G12 0YN, United Kingdom
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The Ottawa Hospital Cancer Centre
Ottawa, Ontario, K1H 8L6, Canada
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UCLA Hematology - Oncology Clinic - Westlake Village
Westlake Village, California, 91361, United States
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UCLA Hematology/ Oncology- Pasadena
Pasadena, California, 91105, United States
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UCLA Hematology/Oncology
Los Angeles, California, 90095, United States
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UCLA Hematology/Oncology - Administrative Office
Los Angeles, California, 90024, United States
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UCLA Hematology/Oncology - Santa Barbara
Santa Barbara, California, 93101, United States
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UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California, 94143, United States
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UCSF Medical Center, Investigational Pharmacy
San Francisco, California, 94158, United States
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US Oncology Investigational Products Center (IPC)
Irving, Texas, 75063, United States
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University of Washington Medical Center
Seattle, Washington, 98195, United States
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UniversitätsSpital Zürich Dermatologische Klinik
Zurich, CH-8091, Switzerland
Conditions
Explore the condition pages connected to this study.