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Gum treatment may slow memory loss in seniors

NCT ID NCT03755362

Prevention Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether intensive treatment for gum disease (periodontitis) could prevent dementia in older adults who already have mild cognitive impairment and narrowed neck arteries. Participants received either standard dental care or deep cleaning and root planing. The trial was terminated early, so results are limited, but the idea is that reducing gum inflammation might protect brain health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intensive dental cleaning and root planing
What this could lead to
If successful, this could show that treating gum disease helps slow cognitive decline and reduce dementia risk in older adults.
What could go wrong
The trial was terminated early with only 26 participants, so results are limited. It is unclear if intensive dental treatment truly affects cognition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

26 people

The number who actually took part.

Started

Apr 2019

Finished

Feb 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age equal to or greater than 65 years. * Body Mass Index 18-35 kg/m2 * Mild to moderate periodontitis * Mild to moderate cognitive impairment on Montreal Cognitive Assessment (MoCA) -range greater than or equal to 17 and less than or equal to 26 (i.e., range from 17-26). * Detectable carotid plaque and carotid artery stenosis \<70% as diagnosed by doppler ultrasound. * Able to perform prescribed dental hygiene and travel to medical center as required to participate in the study. Exclusion Criteria: * Inability to provide informed consent. * Subjects with inability to perform cognitive and other research testing * Prior stroke, depression (CESD \>16), neurologic or psychiatric disease that would affect cognitive testing, participation, and compliance to the research study. * Subjects requiring chronic treatment with systemic corticosteroids or other systemic immunosuppressive drugs or drugs that would affect the dental treatments in the protocol are excluded. * Subjects requiring essential dental care (e.g., treatment for grossly decayed teeth, broken teeth, dental abscesses, peri-apical infections, other dental infections). * Inability to perform FDG-PET due to renal disease (eGFR \<30 mL/min/1.75m2). * Receiving anticoagulant therapy (Warfarin) with an INR greater than 3.3 at time of dental treatment or with a bleeding disorder, or other diseases that may interfere with dental therapy. * Subjects with medical conditions that the clinicians feel would limit their ability to participate.

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Conditions

The condition(s) this trial relates to.

carotid stenosis Cognitive Dysfunction periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carotid stenosis Mild cognitive impairment Periodontitis

Contacts and locations

Locations

  • University of Maryland - Administrative Center

    Baltimore, Maryland, 21201, United States

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