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Immunotherapy boosts standard treatment for head and neck cancer in early trial

NCT ID NCT02586207

First seen Nov 01, 2025 · Last updated Jun 18, 2026 · Updated 34 times

Summary

This early-phase trial tested whether adding the immunotherapy drug pembrolizumab to standard chemoradiation is safe and effective for people with advanced head and neck cancer. 59 participants received pembrolizumab before, during, and after their regular treatment. The goal was to see if this combination could improve tumor shrinkage and control the disease, while monitoring side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Sanford Health Cancer Center

    Sioux Falls, South Dakota, 57104, United States

  • Sanford-Bismarck Medical Center

    Bismarck, North Dakota, 58501, United States

  • Sanford-Roger Maris Cancer Center

    Fargo, North Dakota, 58122, United States

  • UCSD Moores Cancer Center

    La Jolla, California, 92093-0698, United States

Conditions

The condition(s) this trial relates to.

head and neck cancer Head and Neck Neoplasms head and neck squamous cell carcinoma hypopharynx cancer laryngeal carcinoma laryngeal disorder laryngeal neoplasm larynx cancer Mouth Neoplasms oral cavity cancer oropharynx cancer squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.