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Pre-Root canal painkiller cuts Post-Procedure pain, study finds

NCT ID NCT07271654

Symptom relief Sponsor: College of Physicians and Surgeons Pakistan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether taking a single dose of the painkiller diclofenac before a root canal can reduce pain afterward. 160 adults with tooth pain from irreversible pulpitis were split into two groups: one took 100 mg of diclofenac 30 minutes before the procedure, and the other did not. The results showed that those who took the medicine were much more likely to be pain-free at 6 and 12 hours after the root canal.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Diclofenac Sodium
What this could lead to
If confirmed, taking a single dose of diclofenac before a root canal could help many people have a more comfortable recovery.
What could go wrong
This is a small, completed trial. Results may not apply to all patients or settings, and diclofenac can cause side effects like stomach upset or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

160 people

The number who actually took part.

Started

Aug 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria:Pakistani nationals aged 20-60 years. Diagnosis of irreversible pulpitis in a vital tooth (single or multi-rooted), confirmed by a positive cold test. No evidence of periapical abscess on radiographs. - Exclusion Criteria:Prior use of analgesics within a specified timeframe Presence of periodontal disease. Current use of prophylactic antibiotics. Pregnancy or lactation. Mental disabilities. Systemic illnesses contraindicating endodontic therapy. Known hypersensitivity or adverse reaction to NSAIDs. \-

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulpitis - irreversible

Contacts and locations

Locations

  • Saidu College of dentistry,Swat

    Swat, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.