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Ozone-Flushed jaws: new procedure aims to ease TMJ pain

NCT ID NCT07666282

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether using ozonated water to flush the jaw joint (arthrocentesis) works better than the standard Ringer's solution for people with a displaced jaw disc that snaps back into place. Thirty adults with TMJ pain and limited mouth opening were treated. The main goal was to see if ozonated water reduces pain more effectively and improves jaw function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ozonated water
What this could lead to
If it works, this could offer a more effective, minimally invasive procedure to reduce jaw pain and improve mouth opening for people with TMJ disorders.
What could go wrong
This is a small, completed trial with only 30 participants, so results may not apply to everyone. The procedure is still experimental and may not be widely available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Nov 2024

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 18-65 years, with no gender preference. * A main temporomandibular joint (TMJ) complaint that is diagnosed as disc displacement with reduction and arthralgia according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). * Presence of unilateral or bilateral temporomandibular disorder. * American Society of Anesthesiologists (ASA) class I and II patients who are fit for general anesthesia. * No improvement with conservative treatment for 3 months. * Free of magnetic resonance imaging (MRI) contraindications. * No previous surgeries to the TMJ. Exclusion Criteria: * History of systemic diseases that affect the TMJ such as rheumatoid arthritis and osteoarthritis. * Restricted mouth opening due to muscle spasm. * Developmental or congenital TMJ disorders. * Benign or malignant TMJ lesions.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior disc displacement Conventional arthrocentesis Ozonated water arthrocentesis Temporomandibular joint

Contacts and locations

Locations

  • Ain Shams University

    Cairo, 11591, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.