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Orange juice study could unlock secrets of gut health

NCT ID NCT06430138

Knowledge-focused Sponsor: University of Ulster Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study investigates how polyphenols from oranges are absorbed and used by the body, especially in the gut. Researchers will compare healthy adults with a colon to those without a colon (ileostomates) after drinking orange juice. The goal is to understand how these compounds affect gut health and could lead to new food products.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Orange juice (polyphenols)
What this could lead to
If successful, this could help develop new food products that improve gut health.
What could go wrong
This is a small, early-stage study with only 20 participants, so results may not apply broadly. It focuses on understanding digestion, not treating a disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Apr 2024

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: (ileostomates) * Adult with an ileostomy, ≥1.5-years post-operative * Aged 18-75 years at recruitment * Not pregnant / lactating * No learning or other disabilities * Not currently taking antibiotics * Not currently taking plant-based dietary supplements * Not currently taking any prescribed medications that would prevent overnight fasting Inclusion Criteria Healthy adults; no pre-existing chronic disease (GI related) * Aged 18-75 years at recruitment * Not pregnant / lactating * No learning or other disabilities * Not currently taking antibiotics * Not currently taking plant-based dietary supplements * Not currently taking any prescribed medications that would prevent overnight fasting Exclusion criteria (Ileostomates): * Adults \<18 or \>75 years at recruitment * Ileostomy, \<1.5 years post-operative * Pregnant/lactating females * Adults with learning or other disabilities * Citrus fruit (orange) allergy or sensitivity * Currently taking antibiotics * Currently taking plant-based dietary supplements * Currently taking any prescribed medications that would prevent overnight fasting Exclusion criteria (Healthy adults): * Adults \<18 or \>70 years at recruitment * Pregnant/lactating females * Adults with learning or other disabilities * Citrus fruit (orange) allergy or sensitivity * Currently taking antibiotics * Currently taking plant-based dietary supplements * Currently taking any prescribed medications that would prevent overnight fasting

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy nutrition

Contacts and locations

Locations

  • Ulster University,Human Intervention Studies Unit,

    Coleraine, Co. Londonderry, BT521SA, United Kingdom

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