Brain mapping breakthrough could revolutionize epilepsy surgery
NCT ID NCT04649008
First seen Feb 16, 2026 · Last updated Jun 23, 2026 · Updated 14 times
Summary
This study combines advanced MRI scans with intracranial EEG recordings to map brain networks in people with drug-resistant epilepsy. Researchers aim to develop noninvasive imaging biomarkers that predict where seizures start and how they spread. The goal is to improve surgical outcomes and pave the way for more personalized, less invasive treatments. The study is recruiting 290 participants at the University of Pennsylvania.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could lead to better, less invasive ways to pinpoint seizure origins and improve epilepsy surgery success.
What could go wrong
This is an early-phase observational study, so it may not directly lead to new treatments. Results may not apply to all epilepsy patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.